Considering the increasing environmental pollution, it is necessary to analyze the activities in the manure chain, from collection to the application. The use of manure as fertilizer is one of the oldest practices in agriculture; however, continuous application increases the risk of contamination. The approach is mainly empirical, and combines fieldwork with the analysis of the regulatory framework in Mexico. A common practice in the Comarca Lagunera is the application at doses up to 150 ton/ha, without pretreatment. Regarding the regulation, manure management is very punctual. Have not been generated incentives to dimension and reduce the environmental impact derived from livestock activities. Take measures established in other countries is a good choice, since proper treatment and manure management to decrease the problems caused.