Numerical analysis for Tube Hydroforming (THF) was developed in this work to predict the behavior of extruded aluminum tube in a forming die for beverage can applications. THF is a metal forming process dependent of three parameters: friction between the tube and the die, internal pressure, and material properties of the tube. Strain hardening is a governing phenomenon that occurs in the plastic deformation process of metals. Hollomon’s equation offers a mathematical description of the metal behavior in the plastic zone. For a proper simulation, experimental determination of the mechanical properties of aluminum 6061-T5 were conducted and test specimens where obtained directly from the aluminum tube. Experimental data were necessary because no sufficient data of the mechanical properties of the tube were available in the literature. Numerical simulations of THF were performed, and the results were compared with analytical results for validation purposes with less than 10% of error.