Correlation of the rs1815739 polymorphism of the ACTNIII gene with the result of two orthopedic treatments in class II malocclusion

Abstract

The presence of polymorphic variations in the ACTNIII gene influences muscle performance and the alpha-actinin-3 fibers, presenting functional consequences of great clinical importance in the stomatognathic complex. The objective of the present study was to determine the frequency of the polymorphism rs1815739 of the ACTNIII gene and its correlation with the results from two orthopedic treatments in class II malocclusion (MoCII). A comparative cross-sectional study was conducted on 66 students, previously diagnosed with MoCII, from eight general secondary schools in the city of Durango, Durango. A capillary blood sample was taken from their index finger for further analysis and genotyping under the polymerase chain reaction with high resolution melting technique (PCR-HRM). The participants were grouped according to genotype and type of bite. The results show that, although no statistically significant correlation (S = 0.057, p = 0.650) was found between the variables under study, it is observed that one of every three subjects presents the homozygous mutant (TT) risk genotype (42%).

https://doi.org/10.15174/au.2019.2165
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References

Alfred, T., Ben‐Shlomo, Y., Cooper, R., Hardy, R., Cooper, C., Deary, I. J., Gunnell D, Harris S.E., Kumari, M., Martin, R.M., Moran, C.N., Pitsiladis, Y.P., Ring, S.M., Sayer, A.A., Smith, G.D., Starr, J.M., Kuh, D, Day I.N.; & HALCyon study team. (2011). ACTN3 genotype, athletic status, and life course physical capability: Meta‐analysis of the published literature and findings from nine studies. Human Mutation, 32(9), 1008-1018.

Amorim, C. E. G., Acuña-Alonzo, V., Salzano, F. M., Bortolini, M. C., & Hünemeier, T. (2015). Differing evolutionary histories of the ACTN3* R577X polymorphism among the major human geographic groups. PloS One, 10(2), e0115449.

Carels, C. (2002). Genética y ortodoncia. Rev Esp Ortod, 32, 285-95.

Eynon, N., Alves, A. J., Yamin, C., Sagiv, M., Duarte, J. A., Oliveira, J., Ayalon, M., Goldhammer, E., Sagiv, M., & Meckel, Y. (2009). Is there an ACE ID–ACTN3 R577X polymorphisms interaction that influences sprint performance?. International journal of sports medicine, 30(12), 888-891.

García García, V. J., Ustrell Torrent, J. M., & Sentís Vilalta, J. (2011). Evaluación de la maloclusión, alteraciones funcionales y hábitos orales en una población escolar: Tarragona y Barcelona. Avances en Odontoestomatologia, 27(2), 75-84.

Garton, F. C., & North, K. N. (2016). The Effect of Heterozygosity for the ACTN3 Null Allele on Human Muscle Performance. Medicine and Science in Sports and Exercise, 48(3), 509-520.

Godel, J. H., Foley, B. F., Nicot, R., Horton, M. J., Barton, E. R., Ferri, J.,Raoul G., Vieira A.R. & Sciote, J. J. (2014). Associations between ACTN3 and OPPERA pain-related genes in malocclusion. Molecular Pain, 10(S1), P4.

Jiménez, V., Darío, I., Villegas, T., Fernanda, L., Álvarez, S., & Gonzalo, L. (2013). Vertical facial growth peaks before the age of 12 and their relation with pubertal development in 44 untreated colombian mestizos. Revista Facultad de Odontología Universidad de Antioquia, 24(2), 289-306.

João, A. F., Caniuqueo Vargas, A., Hernández- Mosqueira, C., da Silva, S. F., Izquierdo, M., Silva- Mella, H., Ramirez-Campillo, R. & Fernandes- Filho, J. (2015). Polimorfismo del Gen ACTN3 y ECA en Seleccionados de Gimnasia de Brasil y Japón. International Journal of Morphology, 33(1), 262-266.

Kim, K., Ahn, N., Park, J., Koh, J., Jung, S., Kim, S., & Moon, S. (2016). Association of angiotensin-converting enzyme I/D and α-actinin-3 R577X genotypes with metabolic syndrome risk factors in Korean children. Obesity Research & Clinical Practice, 10, S125-S132.

Luciano, R.P., Wajchenberg, M., Almeida, S.S., Amorim, C.E., Rodrigues, L.M., Araujo, R.C., Puertas, E.B. & Faloppa, F. (2016). Genetic ACE I/D and ACTN3 R577X polymorphisms and adolescent idiopathic scoliosis. Genetics and Molecular Research: GMR, 15(4).

Muñoz-Hernández, M.J., Burciaga-Nava, J. A., Cuevas-González, J. C., & Zambrano-Galván, G. (2017). Correlación de polimorfismos del gen COL1A2 con fluorosis dental en niños mexicanos. Acta Universitaria, 27(1), 83-87.

Sandoval-García, F., Petri, M.H., Saavedra, M.A., Cruz-Reyes, C.V., Jara-Quezada, L.J., Dávalos-Rodríguez,,I.P., Salazar-Páramo, M., Gámez-Nava, J.I., González-López, L., García-Iglesias, T., Corona-Sánchez, E.G., Zavaleta-Muñiz, S, Vargas-Ramírez, R., Vázquez-Del Mercado, M. & Martín-Márquez, B.T. (2012). The ACTN3 R577X polymorphism is associated with inflammatory myopathies in a Mexican population. Scandinavian Journal of Rheumatology, 41(5), 396-400.

Sciote, J. J., Raoul, G., Ferri, J., Close, J., Horton, M. J., & Rowlerson, A. (2013). Masseter function and skeletal malocclusion. Revue de Stomatologie, de Chirurgie Maxillo-faciale et de Chirurgie Orale, 114(2), 79-85.

Tedaldi, J., Calderón, R., Mayora, L., Quirós, O., Farias, M., Rondón, S., & Lerner, H. (2007). Tratamiento de maloclusiones según el estadio de maduración carpal. Revisión bibliográfica. Revista Latinoamericana de Ortodoncia y Odontopediatría [en línea].

Zebrick, B., Teeramongkolgul, T., Nicot, R., Horton, M.J., Raoul, G., Ferri, J., Vieira, A.R. & Sciote, J.J. (2014). ACTN3 R577X genotypes associate with Class II and deepbite malocclusions. American Journal of Orthodontics and Dentofacial Orthopedics, 146(5), 603-611.