Complejos de Cu(II): Alternativas en la terapia
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Keywords

ICu-coordination complex
Antineoplasic
Adhesion
Microtubules
DNA fragmentation.

Abstract

In this study, the biological activity of new copper (II) phenanthroline compounds bound to amino acids such as glutamicacid, isoleucine and α-methyl dopa was evaluated. To accomplish this, tumor cells from the human lung and two doses of compounds (30 and 60 μg/ml) were applied to cell cultures. Also, immunostaining of microtubules, phalloidin staining of microfilaments, and electrophoresis of genomic DNA were performed. The results showed that compounds of Cu(II) phenanthroline with glutamic acid and α methyl-dopa significantly affected cellular adhesion (by 50% and 45%, respectively) by altering the distribution of microtubules and microfilaments. Evaluation of DNA fragmentation supported the tumor suppressing effect of Cu (II) Phenantroline with glutamicacid and α-Methyl Dopa on human lung cell cultures in vitro in a dose-dependent manner. In conclusion, Cu (II) phenanthroline with glutamicacid and α-Methyl Dopa compounds demonstrated significant influence on cellular activity effects on tumor cells, suggesting that these compounds have the potential to be useful in the suppression of tumors.

https://doi.org/10.15174/au.2009.86
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