Publicado 2026-03-25
Derechos de autor 2026 Jorge Alejandro Sosa Gutiérrez, Cristo Omar Puente Valenzuela, Rolando Adair Facio Campos, Edgar Héctor Olivas Calderón

Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial-SinDerivadas 4.0.
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Resumen
Los adaptógenos son compuestos naturales, principalmente de origen vegetal, que han sido objeto de creciente interés científico por su capacidad para mejorar la resistencia inespecífica del organismo frente al estrés físico, mental y ambiental. Actúan modulando el eje hipotálamo-hipófisis-adrenal (HHA) y otros sistemas neuroendocrinos, promoviendo la homeostasis sin alterar las funciones fisiológicas normales. Investigaciones recientes han documentado efectos beneficiosos de adaptógenos como Panax ginseng, Rhodiola rosea y Withania somnifera en la reducción del estrés, la fatiga y los trastornos del estado de ánimo, así como en la mejora del rendimiento físico y cognitivo. A pesar del respaldo empírico en estudios preclínicos y clínicos, persisten desafíos en cuanto a la estandarización de extractos, mecanismos moleculares específicos y validación clínica a gran escala. Este trabajo revisa la evidencia más reciente sobre los principales adaptógenos, sus mecanismos de acción, aplicaciones terapéuticas y perspectivas futuras.
Referencias
- Abdelwahed, M. T., Hegazy, M. A., & Mohamed, E. H. (2023). Major biochemical constituents of Withania somnifera (ashwagandha) extract: a review of chemical analysis. Reviews in Analytical Chemistry, 42(1). https://doi.org/10.1515/REVAC-2022-0055
- Afewerky, H. K., Ayodeji, A. E., Tiamiyu, B. B., Orege, J. I., Okeke, E. S., Oyejobi, A. O., Ndip, P., & Adeyemi, S. B. (2021). Critical review of the Withania somnifera (L.) Dunal: ethnobotany, pharmacological efficacy, and commercialization significance in Africa. Bulletin of the National Research Centre, 45(1), 1–16. https://doi.org/10.1186/S42269-021-00635-6
- Agapouda, A., Grimm, A., Lejri, I., & Eckert, A. (2022). Rhodiola rosea extract counteracts stress in an adaptogenic response curve manner via elimination of ROS and induction of neurite outgrowth. Oxidative Medicine and Cellular Longevity, 2022(1), 5647599. https://doi.org/10.1155/2022/5647599
- Alanazi, H. H., & Elfaki, E. (2023). The immunomodulatory role of withania somnifera (L.) dunal in inflammatory diseases. Frontiers in Pharmacology, 14, 1084757. https://doi.org/10.3389/FPHAR.2023.1084757
- Al-Eisa, R. A. (2025). A review on selected pharmacological and phytochemical activities of Ashwagandha (Withania somnifera). Egyptian Journal of Veterinary Sciences, 0(0), 1–23. https://doi.org/10.21608/EJVS.2025.311925.2328
- Aminifard, T., Razavi, B. M., & Hosseinzadeh, H. (2021). The effects of ginseng on the metabolic syndrome: an updated review. Food Science & Nutrition, 9(9), 5293-5311. https://doi.org/10.1002/FSN3.2475
- An, L., Yu, Y., He, L., Xiao, X., & Li, P. (2024). Ginsenoside Rb1 deters cell proliferation, induces apoptosis, alleviates oxidative stress, and antimetastasis in oral squamous carcinoma cells. Applied Biochemistry and Biotechnology, 196(11), 7642–7656. https://doi.org/10.1007/S12010-024-04880-Z
- Anghelescu, I. G., Edwards, D., Seifritz, E., & Kasper, S. (2018). Stress management and the role of Rhodiola rosea: a review. International Journal of Psychiatry in Clinical Practice, 22(4), 242–252. https://doi.org/10.1080/13651501.2017.1417442
- Arshad, M. T., Maqsood, S., Ikram, A., & Abdullahi, M. A. (2025). Functional, nutraceutical, and health-endorsing perspectives of Ashwagandha. EFood, 6(3), e70061. https://doi.org/10.1002/EFD2.70061
- Arumugam, V., Vijayakumar, V., Balakrishnan, A., Bhandari, R. B., Boopalan, D., Ponnurangam, R., Sankaralingam, V., & Kuppusamy, M. (2024). Effects of Ashwagandha (Withania Somnifera) on stress and anxiety: a systematic review and meta-analysis. EXPLORE, 20(6), 103062. https://doi.org/10.1016/J.EXPLORE.2024.103062
- Atteeq, M. (2022). Evaluating anticancer properties of Withaferin A—a potent phytochemical. Frontiers in Pharmacology, 13, 975320. https://doi.org/10.3389/FPHAR.2022.975320
- Awang, D., La, Z., Baima, K., Xie, H., Wang, L., Liu, X., Wang, Y., Shi, Y., Zhao, Y., & Gongga, L. (2025). Salidroside from Rhodiola Rosea L. attenuates high-altitude hypoxic myocardial injury via modulating oxidative stress and Akt/Gsk-3β signaling. https://doi.org/10.2139/SSRN.5384513
- Bai, R., Zhao, Z., Han, X., Shang, M., Liu, G., Xu, F., & Cai, S. (2025). Therapeutic potential of ginsenosides in anthracycline-induced cardiotoxicity. Molecules, 30(12), 2527. https://doi.org/10.3390/MOLECULES30122527
- Basarrate, S., Monzel, A. S., Smith, J. L. M., Marsland, A. L., Trumpff, C., & Picard, M. (2024). Glucocorticoid and adrenergic receptor distribution across human organs and tissues: a map for stress transduction. Psychosomatic Medicine, 86(2), 89–98. https://doi.org/10.1097/PSY.0000000000001275
- Bashir, A., Nabi, M., Tabassum, N., Afzal, S., & Ayoub, M. (2023). An updated review on phytochemistry and molecular targets of Withania somnifera (L.) Dunal (Ashwagandha). Frontiers in Pharmacology, 14, 1049334. https://doi.org/10.3389/FPHAR.2023.1049334
- Basudkar, V., Gujrati, G., Ajgaonkar, S., Gandhi, M., Mehta, D., & Nair, S. (2024). Emerging vistas for the nutraceutical Withania somnifera in inflammaging. Pharmaceuticals, 17(5), 597. https://doi.org/10.3390/PH17050597
- Bernatoniene, J., Jakstas, V., & Kopustinskiene, D. M. (2023). Phenolic compounds of Rhodiola rosea L. as the potential alternative therapy in the treatment of chronic diseases. International Journal of Molecular Sciences, 24(15), 12293. https://doi.org/10.3390/IJMS241512293
- Bian, S., Liu, M., Yang, S., Lu, S., Wang, S., Bai, X., Zhao, D., & Wang, J. (2021). 20(S)-Ginsenoside Rh2-induced apoptosis and protective autophagy in cervical cancer cells by inhibiting AMPK/mTOR pathway. Bioscience, Biotechnology, and Biochemistry, 86(1), 92–103. https://doi.org/10.1093/BBB/ZBAB189
- Bian, X. B., Yu, P. C., Yang, X. H., Han, L., Wang, Q. Y., Zhang, L., Zhang, L. X., & Sun, X. (2023). The effect of ginsenosides on liver injury in preclinical studies: a systematic review and meta-analysis. Frontiers in Pharmacology, 14, 1184774. https://doi.org/10.3389/FPHAR.2023.1184774
- Bilia, A. R., & Bergonzi, M. C. (2019). The G115 standardized ginseng extract: an example for safety, efficacy, and quality of an herbal medicine. Journal of Ginseng Research, 44(2), 179-193. https://doi.org/10.1016/J.JGR.2019.06.003
- Cai, J., Huang, K., Han, S., Chen, R., Li, Z., Chen, Y., Chen, B., Li, S., Xinhua, L., & Yao, H. (2022). A comprehensive system review of pharmacological effects and relative mechanisms of Ginsenoside Re: recent advances and future perspectives. Phytomedicine, 102, 154119. https://doi.org/10.1016/J.PHYMED.2022.154119
- Che, W., Wojitas, L., Shan, C., & Lopchuk, J. M. (2024). Divergent synthesis of complex withanolides enabled by a scalable route and late-stage functionalization. Science Advances, 10(26), eadp9375. https://doi.org/10.1126/SCIADV.ADP9375
- Cheah, K. L., Norhayati, M. N., Yaacob, L. H., & Rahman, R. A. (2021). Effect of Ashwagandha (Withania somnifera) extract on sleep: a systematic review and meta-analysis. PLOS ONE, 16(9), e0257843. https://doi.org/10.1371/JOURNAL.PONE.0257843
- Chen, P., Liu, M., Xiao, H., Luo, T., Ling, H., Chen, X., Li, Z., Xu, S., Li, Z., & Deng, J. (2025). Ginsenoside Re ameliorates cardiac hypertrophy by regulating CaSR-mediated signaling pathway. International Journal of Drug Discovery and Pharmacology, 4(1), 2504000183. https://doi.org/10.53941/IJDDP.2025.100006
- Chen, Q., Yang, C., Wang, D., Luo, S., & Ma, S. (2025). Rhodiola rosea stimulates brain microcirculation in rats with hypoxic brain injury at high altitude. Pakistan Journal of Zoology, 57(4), 1883–1888. https://doi.org/10.17582/JOURNAL.PJZ/20240206130209
- Chen, W., Balan, P., & Popovich, D. G. (2020). Comparison of ginsenoside components of various tissues of New Zealand forest-grown Asian ginseng (Panax Ginseng) and American ginseng (Panax Quinquefolium L.). Biomolecules, 10(3), 372. https://doi.org/10.3390/BIOM10030372
- Chen, Y., Tang, M., Yuan, S., Fu, S., Li, Y., Li, Y., Wang, Q., Cao, Y., Liu, L., & Zhang, Q. (2022). Rhodiola rosea: a therapeutic candidate on cardiovascular diseases. Oxidative Medicine and Cellular Longevity, 2022(1), 1348795. https://doi.org/10.1155/2022/1348795
- Chopra, P., Chhillar, H., Kim, Y. J., Jo, I. H., Kim, S. T., & Gupta, R. (2023). Phytochemistry of ginsenosides: recent advancements and emerging roles. Critical Reviews in Food Science and Nutrition, 63(5), 613–640. https://doi.org/10.1080/10408398.2021.1952159
- Chu, L. L., Montecillo, J. A. V., & Bae, H. (2020). Recent advances in the metabolic engineering of yeasts for ginsenoside biosynthesis. Frontiers in Bioengineering and Biotechnology, 8, 515823. https://doi.org/10.3389/FBIOE.2020.00139
- Concerto, C., Infortuna, C., Muscatello, M. R. A., Bruno, A., Zoccali, R., Chusid, E., Aguglia, E., & Battaglia, F. (2018). Exploring the effect of adaptogenic Rhodiola Rosea extract on neuroplasticity in humans. Complementary Therapies in Medicine, 41, 141–146. https://doi.org/10.1016/j.ctim.2018.09.013
- Cong, L., Ma, J., Zhang, Y., Zhou, Y., Cong, X., & Hao, M. (2023). Effect of anti-skin disorders of ginsenosides- A systematic review. Journal of Ginseng Research, 47(5), 605–614. https://doi.org/10.1016/J.JGR.2023.04.005
- Cui, J., Shan, R., Cao, Y., Zhou, Y., Liu, C., & Fan, Y. (2021). Protective effects of ginsenoside Rg2 against memory impairment and neuronal death induced by Aβ25-35 in rats. Journal of Ethnopharmacology, 266, 113466. https://doi.org/10.1016/J.JEP.2020.113466
- Dai, Y. L., Qiao, M. D., Yu, P., Zheng, F., Yue, H., & Liu, S. Y. (2020). Comparing eight types of ginsenosides in ginseng of different plant ages and regions using RRLC-Q-TOF MS/MS. Journal of Ginseng Research, 44(2), 205–214. https://doi.org/10.1016/J.JGR.2017.11.001
- Dar, N. J., Bhat, J. A., Satti, N. K., Sharma, P. R., Hamid, A., & Ahmad, M. (2017). Withanone, an active constituent from Withania somnifera, affords protection against NMDA-induced excitotoxicity in neuron-like cells. Molecular Neurobiology, 54(7), 5061–5073. https://doi.org/10.1007/S12035-016-0044-7
- De Oliveira, B., de Oliveira, A. R., Miola, V. F. B., Gissoni, L. M., Spilla, C. S. G., & Barbalho, S. M. (2022). Panax ginseng and aging related disorders: a systematic review. Experimental Gerontology, 161, 111731. https://doi.org/10.1016/J.EXGER.2022.111731
- Della Porta, M., Maier, J. A., & Cazzola, R. (2023). Effects of Withania somnifera on cortisol levels in stressed human subjects: a systematic review. Nutrients, 15(24), 5015. https://doi.org/10.3390/NU15245015
- Deshpande, A., Irani, N., Balkrishnan, R., & Benny, I. R. (2020). A randomized, double blind, placebo controlled study to evaluate the effects of ashwagandha (Withania somnifera) extract on sleep quality in healthy adults. Sleep Medicine, 72, 28–36. https://doi.org/10.1016/J.SLEEP.2020.03.012
- Dimpfel, W., Schombert, L., & Panossian, A. G. (2018). Assessing the quality and potential efficacy of commercial extracts of Rhodiola rosea L. by analyzing the salidroside and rosavin content and the electrophysiological activity in hippocampal long-term potentiation, a synaptic model of memory. Frontiers in Pharmacology, 9, 425. https://doi.org/10.3389/FPHAR.2018.00425
- Dinel, A. L., Guinobert, I., Lucas, C., Blondeau, C., Bardot, V., Ripoche, I., Berthomier, L., Pallet, V., Layé, S., & Joffre, C. (2019). Reduction of acute mild stress corticosterone response and changes in stress-responsive gene expression in male Balb/c mice after repeated administration of a Rhodiola rosea L. root extract. Food Science & Nutrition, 7(11), 3827–3841. https://doi.org/10.1002/FSN3.1249
- Dipankar, S. P., Dani, M. M., Anirudhan, R., Tripathi, D., Mishra, C., & Devi, S. H. (2025). Pharmacological insights into Ashwagandha (Withania somnifera): a review of its immunomodulatory and neuroprotective properties. Cureus, 17(8), e89856. https://doi.org/10.7759/CUREUS.89856
- Dongre, S., Langade, D., & Bhattacharyya, S. (2015). Efficacy and safety of Ashwagandha (Withania somnifera) root extract in improving sexual function in women: a pilot study. BioMed Research International, 2015(1), 284154. https://doi.org/10.1155/2015/284154
- Dormal, V., Jonniaux, L., Buchet, M., Simar, L., Copine, S., & Deldicque, L. (2025). Effect of hydroponically grown red panax ginseng on perceived stress level, emotional processing, and cognitive functions in moderately stressed adults: a randomized, double-blind, placebo-controlled study. Nutrients, 17(6), 955. https://doi.org/10.3390/NU17060955
- Dutta, R., Khalil, R., Green, R., Mohapatra, S. S., & Mohapatra, S. (2019). Withania Somnifera (Ashwagandha) and Withaferin A: potential in integrative oncology. International Journal of Molecular Sciences, 20(21), 5310. https://doi.org/10.3390/IJMS20215310
- Edwards, D., Heufelder, A., & Zimmermann, A. (2012). Therapeutic effects and safety of Rhodiola rosea extract WS® 1375 in subjects with life-stress symptoms--results of an open-label study. Phytotherapy Research, 26(8), 1220–1225. https://doi.org/10.1002/PTR.3712
- Er, B., Ozmen, B., Sahin, E., Orhan, C., Sahin, N., Morde, A. A., Padigaru, M., & Sahin, K. (2025). A novel Ashwagandha (Withania somnifera) formulation mitigates sleep deprivation-induced cognitive impairment and oxidative stress in a rat model. Biomolecules, 15(5), 710. https://doi.org/10.3390/BIOM15050710
- Esmaealzadeh, N., Iranpanah, A., Sarris, J., & Rahimi, R. (2022). A literature review of the studies concerning selected plant-derived adaptogens and their general function in body with a focus on animal studies. Phytomedicine, 105, 154354. https://doi.org/10.1016/j.phymed.2022.154354
- Fan, S., Zhang, Z., Su, H., Xu, P., Qi, H., Zhao, D., & Li, X. (2020). Panax ginseng clinical trials: current status and future perspectives. Biomedicine & Pharmacotherapy, 132, 110832. https://doi.org/10.1016/J.BIOPHA.2020.110832
- Fan, W., Fan, L., Wang, Z., Mei, Y., Liu, L., Li, L., Yang, L., & Wang, Z. (2024). Rare ginsenosides: a unique perspective of ginseng research. Journal of Advanced Research, 66, 303-328. https://doi.org/10.1016/J.JARE.2024.01.003
- Fang, F., Chen, X., Huang, T., Lue, L. F., Luddy, J. S., & Yan, S. S. (2011). Multi-faced neuroprotective effects of Ginsenoside Rg1 in an Alzheimer mouse model. Biochimica et Biophysica Acta, 1822(2), 286.
- https://doi.org/10.1016/J.BBADIS.2011.10.004
- Fang, X., Zhou, X., Wang, Y., Zhang, W., Wu, H., Xu, L., Sun, M., & Xiao, H. (2024). Determining the genetic basis of ginsenosides variation during ginseng domestication by evolutionary transcriptomics. Industrial Crops and Products, 212, 118369. https://doi.org/10.1016/J.INDCROP.2024.118369
- Fanibunda, S. E., Kukkemane, K., Ghai, U., Kolthur-Seetharam, U., Hingorani, L., Vaidya, A. D. B., & Vaidya, V. A. (2025). Withania somnifera regulates mitochondrial biogenesis and energetics in rat cortical neurons: role of BDNF and SIRT1. Molecular Neurobiology, 62(8), 10277–10295. https://doi.org/10.1007/S12035-025-04920-7
- Feng, H., Xue, M., Deng, H., Cheng, S., Hu, Y., & Zhou, C. (2022). Ginsenoside and its therapeutic potential for cognitive impairment. Biomolecules, 12(9), 1310. https://doi.org/10.3390/BIOM12091310
- Ferreira, J. F., Ferreira, R. M., Maia, F., Fernandes, L. G., Leão, C., & Pimenta, N. (2025). Biopsychological effects of Ashwagandha (Withania somnifera) in athletes and healthy individuals: a systematic review. Muscles, 4(3), 24. https://doi.org/10.3390/MUSCLES4030024
- Fu, H., Zhang, Y., An, Q., Wang, D., You, S., Zhao, D., Zhang, J., Wang, C., & Li, M. (2022). Anti-photoaging effect of Rhodiola rosea fermented by Lactobacillus plantarum on UVA-damaged fibroblasts. Nutrients, 14(11), 2324. https://doi.org/10.3390/NU14112324
- Gao, L., Wu, C., Liao, Y., Zhang, S., & Zhao, J. (2021). Herba Rhodiolae alleviates depression via the BDNF/TrkB-GSK-3β signaling pathway. Annals of Translational Medicine, 9(24), 1758–1758. https://doi.org/10.21037/ATM-21-5849
- Gaurav, H., Yadav, D., Maurya, A., Yadav, H., Yadav, R., Shukla, A. C., Sharma, M., Gupta, V. K., & Palazon, J. (2023). Biodiversity, biochemical profiling, and pharmaco-commercial applications of Withania somnifera: a review. Molecules, 28(3), 1208. https://doi.org/10.3390/MOLECULES28031208
- Gębalski, J., Małkowska, M., Graczyk, F., Słomka, A., Piskorska, E., Gawenda-Kempczyńska, D., Kondrzycka-Dąda, A., Bogucka-Kocka, A., Strzemski, M., Sowa, I., Wójciak, M., Grzyb, S., Krolik, K., Ptaszyńska, A. A., & Załuski, D. (2023). Phenolic compounds and antioxidant and anti-enzymatic activities of selected adaptogenic plants from South America, Asia, and Africa. Molecules, 28(16), 6004. https://doi.org/10.3390/MOLECULES28166004
- Geng, B., Zhao, M., Wang, J., Zhong, T., Kang, C., Wang, Z., Ma, X., & Xia, T. (2024). Ginsenoside Rh2 promotes cell apoptosis in T-cell acute lymphocytic leukaemia by MAPK and PI3K/AKT signalling pathways. Natural Product Research. https://doi.org/10.1080/14786419.2024.2440537
- Gerontakos, S. E., Wardle, J., & Casteleijn, D. (2020). A critical review to identify the domains used to measure the effect and outcome of adaptogenic herbal medicines. Advances in Integrative Medicine, 6(1), 133-134. https://doi.org/10.1016/j.aimed.2019.03.389
- Girme, A., Saste, G., Pawar, S., Balasubramaniam, A. K., Musande, K., Darji, B., Satti, N. K., Verma, M. K., Anand, R., Singh, R., Vishwakarma, R. A., & Hingorani, L. (2020). Investigating 11 withanosides and withanolides by UHPLC–PDA and mass fragmentation studies from Ashwagandha (Withania somnifera). ACS Omega, 5(43), 27933–27943. https://doi.org/10.1021/ACSOMEGA.0C03266
- Gokdemir, G. S., Seker, U., Baksi, N., Baylan, M., Demirtaş, B., & Gokdemir, M. T. (2026). Antidepressant-like effects of Ashwagandha (Withania Somnifera) on chronic unpredictable mild stress-induced depression in adolescent rats. Psychopharmacology, 243, 117–132. https://doi.org/10.1007/S00213-025-06844-5
- Gómez, A., Fernandez-Lazaro, D., Adams, D. P., Monserdà-Vilaró, A., & Fernandez-Lazaro, C. I. (2023). Effects of Withania somnifera (Ashwagandha) on hematological and biochemical markers, hormonal behavior, and oxidant response in healthy adults: a systematic review. Current Nutrition Reports, 12(3), 465–477. https://doi.org/10.1007/S13668-023-00481-0
- Gong, L., Yin, J., Zhang, Y., Huang, R., Lou, Y., Jiang, H., Sun, L., Jia, J., & Zeng, X. (2022). Neuroprotective mechanisms of ginsenoside Rb1 in central nervous system diseases. Frontiers in Pharmacology, 13, 914352. https://doi.org/10.3389/FPHAR.2022.914352
- Gopukumar, K., Thanawala, S., Somepalli, V., Rao, T. S. S., Thamatam, V. B., & Chauhan, S. (2021). Efficacy and safety of Ashwagandha root extract on cognitive functions in healthy, stressed adults: a randomized, double-blind, placebo-controlled study. Evidence-Based Complementary and Alternative Medicine, 2021(1), 8254344. https://doi.org/10.1155/2021/8254344
- Guo, S., & Rezaei, M. J. (2024). The benefits of ashwagandha (Withania somnifera) supplements on brain function and sports performance. Sports and Exercise Nutrition, 11. https://doi.org/10.3389/FNUT.2024.1439294
- Gupta, M., & Kaur, G. (2016). Aqueous extract from the Withania somnifera leaves as a potential anti-neuroinflammatory agent: a mechanistic study. Journal of Neuroinflammation, 13(193). https://doi.org/10.1186/S12974-016-0650-3
- Gurav, S., Wanjari, M., Bhole, R., Raut, N., Prasad, S., Saoji, S., Chikhale, R., Khanal, P., Pant, A., Ayyanar, M., & Gurav, N. (2023). Ethnological validation of Ashwagandha (Withania somnifera L. Dunal) ghrita as ‘Vajikarana Rasayana’: In-silico, in-vitro and in-vivo approach. Journal of Ethnopharmacology, 304, 116064. https://doi.org/10.1016/J.JEP.2022.116064
- Haber, M., Czachor, A., Kula, P., Juśkiewicz, A., Grelewicz, O., Kucy, N., Servaas, E., Kotula, A., & Siemiątkowski, R. (2024). Ashwagandha as an adaptogen: its influence on sleep patterns, stress response, and anxiety in modern life. Journal of Education, Health and Sport, 68, 55327. https://doi.org/10.12775/JEHS.2024.68.55327
- Han, D., Zhao, Z., Mao, T., Gao, M., Yang, X., & Gao, Y. (2024). Ginsenoside Rg1: a neuroprotective natural dammarane‐type triterpenoid saponin with anti‐depressive properties. CNS Neuroscience & Therapeutics, 30(12), e70150. https://doi.org/10.1111/CNS.70150
- Han, J. Y., Kim, H. J., Kwon, Y. S., & Choi, Y. E. (2011). The Cyt P450 enzyme CYP716A47 catalyzes the formation of protopanaxadiol from dammarenediol-II during ginsenoside biosynthesis in Panax ginseng. Plant and Cell Physiology, 52(12), 2062–2073. https://doi.org/10.1093/PCP/PCR150
- Hasanyn, R. F., Batawi, A. H., Al-Thepyani, M. A., Tash, R., Almuhammadi, A., Alsabban, A. H., & Alghamdi, B. S. (2025). Ashwagandha root extract mitigates fibromyalgia-like symptoms via neurochemical and histological modulation in mice. Cells, 14(18), 1478. https://doi.org/10.3390/CELLS14181478
- Hernández-Santana, A., Pérez-López, V., Zubeldia, J. M., & Jiménez-Del-Rio, M. (2014). A Rhodiola rosea root extract protects skeletal muscle cells against chemically induced oxidative stress by modulating heat shock protein 70 (HSP70) expression. Phytotherapy Research, 28(4), 623–628. https://doi.org/10.1002/PTR.5046
- Hou, J., Cui, C., Kim, S., Sung, C., & Choi, C. (2018). Ginsenoside F1 suppresses astrocytic senescence-associated secretory phenotype. Chemico-Biological Interactions, 283, 75–83.
- https://doi.org/10.1016/J.CBI.2018.02.002
- Hou, J., Yun, Y., Jeon, B., Baek, J., & Kim, S. (2023). Ginsenoside F1-mediated telomere preservation delays cellular senescence. International Journal of Molecular Sciences, 24(18), 14241.
- https://doi.org/10.3390/IJMS241814241
- Hou, M., Wang, R., Zhao, S., & Wang, Z. (2021). Ginsenosides in Panax genus and their biosynthesis. Acta Pharmaceutica Sinica B, 11(7), 1813–1834. https://doi.org/10.1016/J.APSB.2020.12.017
- Hou, W., Wang, Y., Zheng, P., & Cui, R. (2020). Effects of ginseng on neurological disorders. Frontiers in Cellular Neuroscience, 14, 510085. https://doi.org/10.3389/FNCEL.2020.00055
- Hu, Y., Cho, J. Y., & Kim, M. Y. (2025). Pharmacokinetics and pharmacological activities of protopanaxatriol. Journal of Ginseng Research, 49(6), 613-621. https://doi.org/10.1016/J.JGR.2025.07.004
- Huang, C., Li, P., Yang, X., Niu, T., Zhao, S., Yang, L., Wang, R., & Wang, Z. (2023). Integrated transcriptome and proteome analyses reveal candidate genes for ginsenoside biosynthesis in Panax japonicus C. A. Meyer. Frontiers in Plant Science, 13, 1106145. https://doi.org/10.3389/FPLS.2022.1106145
- Huang, X., Daneshi, M., Falahatzadeh, M., & Rounagh, M. (2025). The effect of ginseng supplementation and health outcomes: a GRADE-assessed systematic review and meta-analysis of randomized controlled trials. Journal of Functional Foods, 129, 106879. https://doi.org/10.1016/J.JFF.2025.106879
- Hung, S. K., Perry, R., & Ernst, E. (2011). The effectiveness and efficacy of Rhodiola rosea L.: a systematic review of randomized clinical trials. Phytomedicine, 18(4), 235–244. https://doi.org/10.1016/j.phymed.2010.08.014
- Hyun, S. H., Bhilare, K. D., In, G., Park, C. K., & Kim, J. H. (2021). Effects of Panax ginseng and ginsenosides on oxidative stress and cardiovascular diseases: pharmacological and therapeutic roles. Journal of Ginseng Research, 46(1), 33-38. https://doi.org/10.1016/J.JGR.2021.07.007
- Irfan, M., Kwak, Y. S., Han, C. K., Hyun, S. H., & Rhee, M. H. (2020). Adaptogenic effects of Panax ginseng on modulation of cardiovascular functions. Journal of Ginseng Research, 44(4), 538–543. https://doi.org/10.1016/J.JGR.2020.03.001
- Jang, W. Y., Hwang, J. Y., & Cho, J. Y. (2023). Ginsenosides from Panax ginseng as key modulators of NF-κB signaling are powerful anti-inflammatory and anticancer agents. International Journal of Molecular Sciences, 24(7), 6119. https://doi.org/10.3390/IJMS24076119
- Jayawardena, R., Weerasinghe, K., & Sooriyaarachchi, P. (2025). The effect of Ashwagandha (Withania somnifera) on sports performance: a systematic review and meta-analysis. Spor Hekimliği Dergisi, 60(2), 064–073. https://doi.org/10.47447/TJSM.0862
- Jeong, J. S., Kim, J. W., Kim, J. H., Kim, C. Y., Chung, E. H., Boo, S. Y., Giorgi, M., Ko, J. W., & Kim, T. W. (2025). Pharmacokinetic variability of 20(S)-protopanaxadiol-type ginsenosides Rb1, rd, and compound K from Korean red ginseng in experimental rodents. Scientific Reports, 15(1), 28072. https://doi.org/10.1038/S41598-025-13873-9
- Jo, H., Jang, D., Park, S. K., Lee, M. G., Cha, B., Park, C., Shin, Y. S., Park, H., Baek, J., Heo, H., Brito, S., Hwan, H. G., Chae, S., Yan, S., Lee, C., Min, C. K., & Bin, B. H. (2021). Ginsenoside 20(S)-protopanaxadiol induces cell death in human endometrial cancer cells via apoptosis. Journal of Ginseng Research, 45(1), 126–133. https://doi.org/10.1016/j.jgr.2020.02.002
- Jówko, E., Sadowski, J., Długołęcka, B., Gierczuk, D., Opaszowski, B., & Cieśliński, I. (2018). Effects of Rhodiola rosea supplementation on mental performance, physical capacity, and oxidative stress biomarkers in healthy men. Journal of Sport and Health Science, 7(4), 473–480. https://doi.org/10.1016/J.JSHS.2016.05.005
- Jurcău, R., Lambinet, M., Jurcău, I., & Rusu, L. D. (2019). A PubMed evaluation of the Rhodiola rosea adaptogen. Health, Sports & Rehabilitation Medicine, 20(4), 174–178. https://doi.org/10.26659/PM3.2019.20.4.174
- Jurcău, R. N., Jurcău, I. M., Lambinet, M., Colceriu, N. A., Trif, F. G., & Kwak, D. H. (2025). Modulatory role of Rhodiola Rosea in anxiety and stress: a PubMed approach. BULETIN ŞTIINŢIFIC SERIA A Fascicula Pedagogie-Psihologie-Metodică, 25, 211–218. https://doi.org/10.37193/BS-PPM.25.19
- Kang, O. J., & Kim, J. S. (2016). Comparison of ginsenoside contents in different parts of Korean ginseng (Panax ginseng C.A. Meyer). Preventive Nutrition and Food Science, 21(4), 389–392. https://doi.org/10.3746/PNF.2016.21.4.389
- Kang, S., & Min, H. (2012). Ginseng, the “Immunity Boost”: the effects of Panax ginseng on immune system. Journal of Ginseng Research, 36(4), 354-368. https://doi.org/10.5142/JGR.2012.36.4.354
- Kanyaiya, M., Digambar, S. P., Arora, S., Kapila, S., & Singh, R. R. B. (2014). In vivo, effect of herb (Withania somnifera) on immunomodulatory and antioxidative potential of milk in mice. Food and Agricultural Immunology, 25(3), 443–452. https://doi.org/10.1080/09540105.2013.837032
- Karimi, M., Barjasteh, A. H., Shariatzadeh, M., Taha, S. R., Fazlollahpour-naghibi, A., Rezaei, P., Aghaei, M., Ghanbari, M., & Pourhanifeh, M. H. (2025). Ginsenosides and gastrointestinal cancers: a novel therapeutic strategy in cancer therapy. Pathology - Research and Practice, 272, 156078. https://doi.org/10.1016/J.PRP.2025.156078
- Kasprzyk, P. G., Tremaine, L., Fahmi, O. A., & Weng, J. K. (2023). In Vitro evaluation of the potential for drug interactions by salidroside. Nutrients, 15(17), 3723. https://doi.org/10.3390/NU15173723
- Kaur, J., Seshadri, S., Golla, K. H., & Sampara, P. (2022). Efficacy and safety of standardized Ashwagandha (Withania somnifera) root extract on reducing stress and anxiety in domestic dogs: a randomized controlled trial. Journal of Veterinary Behavior, 51, 8–15. https://doi.org/10.1016/J.JVEB.2022.03.002
- Khalil, H. M. A., Eliwa, H. A., El-Shiekh, R. A., Al-Mokaddem, A. K., Hassan, M., Tawfek, A. M., & El-Maadawy, W. H. (2021). Ashwagandha (Withania somnifera) root extract attenuates hepatic and cognitive deficits in thioacetamide-induced rat model of hepatic encephalopathy via induction of Nrf2/HO-1 and mitigation of NF-κB/MAPK signaling pathways. Journal of Ethnopharmacology, 277, 114141. https://doi.org/10.1016/J.JEP.2021.114141
- Khan, M. A., Ahmed, R. S., Chandra, N., Arora, V. K., & Ali, A. (2019). In vivo, extract from Withania somnifera root ameliorates arthritis via regulation of key immune mediators of inflammation in experimental model of arthritis. Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 18(1), 55. https://doi.org/10.2174/1871523017666181116092934
- Kim, D., Kim, M., Raña, G. S., & Han, J. (2018). Seasonal variation and possible biosynthetic pathway of ginsenosides in Korean ginseng Panax ginseng Meyer. Molecules, 23(7), 1824. https://doi.org/10.3390/MOLECULES23071824
- Kim, H., Choi, H. S., Han, K., Sim, W., Suh, H. J., & Ahn, Y. (2025). Ashwagandha (Withania somnifera (L.) dunal) root extract containing withanolide a alleviates depression-like behavior in mice by enhancing the brain-derived neurotrophic factor pathway under unexpected chronic mild stress. Journal of Ethnopharmacology, 340, 119224. https://doi.org/10.1016/J.JEP.2024.119224
- Kim, H. W., Kim, D. H., Ryu, B., Chung, Y. J., Lee, K., Kim, Y. C., Lee, J. W., Kim, D. H., Jang, W., Cho, W., Shim, H., Sung, S. H., Yang, T. J., & Kang, K. B. (2024). Mass spectrometry-based ginsenoside profiling: recent applications, limitations, and perspectives. Journal of Ginseng Research, 48(2), 149-162. https://doi.org/10.1016/J.JGR.2024.01.004
- Kim, J. H., Yi, Y. S., Kim, M. Y., & Cho, J. Y. (2017). Role of ginsenosides, the main active components of Panax ginseng, in inflammatory responses and diseases. Journal of Ginseng Research, 41(4), 435–443. https://doi.org/10.1016/J.JGR.2016.08.004
- Kim, J. K., Choi, M. S., Park, H. S., Kee, K. H., Kim, D. H., & Yoo, H. H. (2023). Pharmacokinetic profiling of ginsenosides, Rb1, Rd, and Rg3, in mice with antibiotic-induced gut microbiota alterations: implications for variability in the therapeutic efficacy of red ginseng extracts. Foods, 12(23), 43-42. https://doi.org/10.3390/FOODS12234342
- Kim, Y. J., Zhang, D., & Yang, D. C. (2015). Biosynthesis and biotechnological production of ginsenosides. Biotechnology Advances, 33(6), 717–735. https://doi.org/10.1016/J.BIOTECHADV.2015.03.001
- Kim, Y. S., Woo, J. Y., Han, C. K., & Chang, I. M. (2015). Safety analysis of Panax Ginseng in randomized clinical trials: a systematic review. Medicines, 2(2), 106-126. https://doi.org/10.3390/MEDICINES2020106
- Krishnaraju, A. V., Somepalli, V., Thanawala, S., & Shah, R. (2023). Efficacy and anti-inflammatory activity of ashwagandha sustained-release formulation on depression and anxiety induced by chronic unpredictable stress: in vivo and in vitro studies. Journal of Experimental Pharmacology, 15, 291. https://doi.org/10.2147/JEP.S407906
- Kumar, P., Sharma, R., & Garg, N. (2022). Withania somnifera - a magic plant targeting multiple pathways in cancer related inflammation. Phytomedicine, 101, 154137. https://doi.org/10.1016/j.phymed.2022.154137
- Kumar, S., Mathew, S. O., Aharwal, R. P., Tulli, H. S., Mohan, C. D., Sethi, G., Ahn, K. S., Webber, K., Sandhu, S. S., & Bishayee, A. (2023). Withaferin A: a pleiotropic anticancer agent from the Indian medicinal plant Withania somnifera (L.) Dunal. Pharmaceuticals, 16(2), 160. https://doi.org/10.3390/PH16020160
- Langade, D., Kanchi, S., Salve, J., Debnath, K., & Ambegaokar, D. (2019). Efficacy and safety of Ashwagandha (Withania somnifera) root extract in insomnia and anxiety: a double-blind, randomized, placebo-controlled study. Cureus, 11(9). https://doi.org/10.7759/CUREUS.5797
- Le, M. H., Ahn, Y. H., Lee, H. J., & Kim, Y. J. (2024). Stem-and-leaf of new hydroponically-cultured ginseng cultivar K-1: a sustainable and innovative resource of ginsenosides for anti-inflammatory agents. Journal of Ginseng Research, 48(6), 616–626. https://doi.org/10.1016/J.JGR.2024.07.001
- Lee, D. H., Ahn, J., Jang, Y. J., Seo, H. D., Ha, T. Y., Kim, M. J., Huh, Y. H., & Jung, C. H. (2020). Withania somnifera extract enhances energy expenditure via improving mitochondrial function in adipose tissue and skeletal muscle. Nutrients, 12(2), 431. https://doi.org/10.3390/NU12020431
- Lee, K., Lee, D., Kim, J. Y., Shim, J. J., Bae, J. W., & Lee, J. H. (2025). Attenuation effect of Withania somnifera extract on restraint stress-induced anxiety-like behavior and hippocampal alterations in mice. International Journal of Molecular Sciences, 26(15), 7317. https://doi.org/10.3390/IJMS26157317
- Lee, N. H., Yoo, S. R., Kim, H. G., Cho, J. H., & Son, C. G. (2012). Safety and tolerability of panax ginseng root extract: a randomized, placebo-controlled, clinical trial in healthy Korean volunteers. Journal of Alternative and Complementary Medicine, 18(11), 1061. https://doi.org/10.1089/ACM.2011.0591
- Lee, R., Kim, J. H., Kim, W. W., Hwang, S. H., Choi, S. H., Kim, J. H., Cho, I. H., Kim, M., & Nah, S. Y. (2024). Emerging evidence that ginseng components improve cognition in subjective memory impairment, mild cognitive impairment, and early Alzheimer’s disease dementia. Journal of Ginseng Research, 48(3), 245–252. https://doi.org/10.1016/J.JGR.2024.02.002
- Lee, S., & Rhee, D. K. (2017). Effects of ginseng on stress-related depression, anxiety, and the hypothalamic–pituitary–adrenal axis. Journal of Ginseng Research, 41(4), 589–594. https://doi.org/10.1016/J.JGR.2017.01.010
- Lee, Y. M., Yoon, H., Park, H. M., Song, B. C., & Yeum, K. J. (2017). Implications of red Panax ginseng in oxidative stress associated chronic diseases. Journal of Ginseng Research, 41(2), 113–119. https://doi.org/10.1016/J.JGR.2016.03.003
- Leonard, M., Dickerson, B., Estes, L., Gonzalez, D. E., Jenkins, V., Johnson, S., Xing, D., Yoo, C., Ko, J., Purpura, M., Jäger, R., Faries, M., Kephart, W., Sowinski, R., Rasmussen, C. J., & Kreider, R. B. (2024). Acute and repeated ashwagandha supplementation improves markers of cognitive function and mood. Nutrients, 16(12), 1813. https://doi.org/10.3390/NU16121813
- Lerose, V., Ponticelli, M., Benedetto, N., Carlucci, V., Lela, L., Tzvetkov, N. T., & Milella, L. (2024). Withania somnifera (L.) Dunal, a potential source of phytochemicals for treating neurodegenerative diseases: a systematic review. Plants, 13(6), 771. https://doi.org/10.3390/PLANTS13060771
- Li, F., Lv, C., Li, Q., Wang, J., Song, D., Liu, P., Zhang, D., & Lu, J. (2017). Chemical and bioactive comparison of flowers of Panax ginseng Meyer, Panax quinquefolius L., and Panax notoginseng Burk. Journal of Ginseng Research, 41(4), 487–495. https://doi.org/10.1016/J.JGR.2016.08.008
- Li, J., Huang, Q., Yao, Y., Ji, P., Mingyao, E., Chen, J., Zhang, Z., Qi, H., Liu, J., Chen, Z., Zhao, D., Zhou, L., & Li, X. (2022). Biotransformation, pharmacokinetics, and pharmacological activities of ginsenoside Rd against multiple diseases. Frontiers in Pharmacology, 13, 909363. https://doi.org/10.3389/FPHAR.2022.909363
- Li, X., Cheng, X., Liao, B., Xu, J., Han, X., Zhang, J., Lin, Z., & Hu, L. (2021). Spatial protein expression of Panax ginseng by in-depth proteomic analysis for ginsenoside biosynthesis and transportation. Journal of Ginseng Research, 45(1), 58–65. https://doi.org/10.1016/J.JGR.2020.01.009
- Li, Y., Pham, V., Bui, M., Song, L., Wu, C., Walia, A., Uchio, E., Smith-Liu, F., & Zi, X. (2017). Rhodiola rosea L.: an herb with anti-stress, anti-aging, and immunostimulating properties for cancer chemoprevention. Current Pharmacology Reports, 3(6), 384. https://doi.org/10.1007/S40495-017-0106-1
- Liang, C. J. W., Woerdenbag, H. J., Ekhart, C., Vitalone, A., & van Hunsel, F. P. A. M. (2025). Safety considerations for natural products with adaptogenic and immunomodulating activities. Pharmaceuticals, 18(8), 1208. https://doi.org/10.3390/PH18081208
- Liang, J., Tang, X., Wan, S., Guo, J., Zhao, P., & Lu, L. (2023). Structure modification of ginsenoside Rh2 and cytostatic activity on cancer cells. ACS Omega, 8(19), 17245–17253. https://doi.org/10.1021/ACSOMEGA.3C01665
- Liao, L. Y., He, Y. F., Li, L., Meng, H., Dong, Y. M., Yi, F., & Xiao, P. G. (2018). A preliminary review of studies on adaptogens: comparison of their bioactivity in TCM with that of ginseng-like herbs used worldwide. Chinese Medicine, 13(57). https://doi.org/10.1186/S13020-018-0214-9
- Limanaqi, F., Biagioni, F., Busceti, C. L., Polzella, M., Fabrizi, C., & Fornai, F. (2020). Potential antidepressant effects of Scutellaria baicalensis, Hericium erinaceus and Rhodiola rosea. Antioxidants, 9(3), 234. https://doi.org/10.3390/ANTIOX9030234
- Liu, S., Chen, W., Zhao, Y., Zong, Y., Li, J., & He, Z. (2023). Research progress on effects of ginsenoside Rg2 and Rh1 on nervous system and related mechanisms. Molecules, 28(23) 7935.
- https://doi.org/10.3390/MOLECULES28237935
- Liu, W., Zhang, S. X., Ai, B., Pan, H. F., Zhang, D., Jiang, Y., Hu, L. H., Sun, L. L., Chen, Z. S., & Lin, L. Z. (2021). Ginsenoside Rg3 promotes cell growth through activation of mTORC1. Frontiers in Cell and Developmental Biology, 9, 730309. https://doi.org/10.3389/FCELL.2021.730309
- Liu, Y., Ju, Y., Wang, Y., Cui, X., Sun, Y., Hu, P., & Chen, Y. (2025). Ginsenoside in the treatment of type 2 diabetes and its complications: a promising traditional Chinese medicine. Frontiers in Pharmacology, 16, 1593780. https://doi.org/10.3389/FPHAR.2025.1593780
- Liu, Y., Zong, X., Huang, J., Guan, Y., Li, Y., Du, T., Liu, K., Kang, X., Dou, C., Sun, X., Wu, R., Wen, L., & Zhang, Y. (2019). Ginsenoside Rb1 regulates prefrontal cortical GABAergic transmission in MPTP-treated mice. Aging, 11(14), 5008–5034. https://doi.org/10.18632/AGING.102095
- Lopresti, A. L., Smith, S. J., & Drummond, P. D. (2022). Modulation of the hypothalamic-pituitary-adrenal (HPA) axis by plants and phytonutrients: a systematic review of human trials. Nutritional Neuroscience, 25(8), 1704–1730. https://doi.org/10.1080/1028415X.2021.1892253
- Lopresti, A. L., Smith, S. J., Malvi, H., & Kodgule, R. (2019). An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: a randomized, double-blind, placebo-controlled study. Medicine, 98(37), e17186. https://doi.org/10.1097/MD.0000000000017186
- Lu, Y., Deng, B., Xu, L., Liu, H., Song, Y., & Lin, F. (2022). Effects of Rhodiola Rosea supplementation on exercise and sport: a systematic review. Frontiers in Nutrition, 9. https://doi.org/10.3389/FNUT.2022.856287
- Lu, Z., Mao, T., Chen, K., Chai, L., Dai, Y., & Liu, K. (2023). Ginsenoside Rc: a potential intervention agent for metabolic syndrome. Journal of Pharmaceutical Analysis, 13(12), 1375–1387. https://doi.org/10.1016/J.JPHA.2023.08.013
- Ma, G. P., Zheng, Q., Xu, M. B., Zhou, X. L., Lu, L., Li, Z. X., & Zheng, G. Q. (2018). Rhodiola rosea L. improves learning and memory function: preclinical evidence and possible mechanisms. Frontiers in Pharmacology, 9, 1415. https://doi.org/10.3389/FPHAR.2018.01415
- Maccioni, R., Cottiglia, F., Maccioni, E., Talani, G., Sanna, E., Bassareo, V., Kasture, S. B., & Acquas, E. (2021). The biologically active compound of Withania somnifera (L.) Dunal, docosanyl ferulate, is endowed with potent anxiolytic properties but devoid of typical benzodiazepine-like side effects. Journal of Psychopharmacology (Oxford, England), 35(10), 1277–1284. https://doi.org/10.1177/02698811211008588
- Maher, S., Choudhary, M. I., Saleem, F., Rasheed, S., Waheed, I., Halim, S. A., Azeem, M., Abdullah, I. Bin, Froeyen, M., Mirza, M. U., & Ahmad, S. (2020). Isolation of antidiabetic Withanolides from Withania coagulans Dunal and their in vitro and in silico validation. Biology, 9(8), 197. https://doi.org/10.3390/BIOLOGY9080197
- Marciniak, A., Nemeczek, S., Walczak, K., Walczak, P., Merkisz, K., Grzybowski, J., Grzywna, N., Jaskuła, K., & Orłowski, W. (2023). Adaptogens-use, history and future. Quality in Sport, 9(1), 19–28. https://doi.org/10.12775/QS.2023.09.01.002
- Mariage, P. A., Hovhannisyan, A., & Panossian, A. G. (2020). Efficacy of panax ginseng meyer herbal preparation hrg80 in preventing and mitigating stress-induced failure of cognitive functions in healthy subjects: a pilot, randomized, double-blind, placebo-controlled crossover trial. Pharmaceuticals, 13(4) 57. https://doi.org/10.3390/PH13040057
- Masi, F., Chianese, G., Hofstetter, R. K., Cavallaro, A. L., Riva, A., Werz, O., & Taglialatela-Scafati, O. (2023). Phytochemical profile and anti-inflammatory activity of a commercially available Rhodiola rosea root extract. Fitoterapia, 166, 105439. https://doi.org/10.1016/J.FITOTE.2023.105439
- McEwen, B. S. (2017). Neurobiological and systemic effects of chronic stress. Chronic Stress (Thousand Oaks, Calif.), 1. https://doi.org/10.1177/2470547017692328
- Mehta, J. P., Kagal, U. A., & Biradar, P. R. (2025). Effect of Withania somnifera on expression of selected genes in hippocampus of male wistar rats subjected to chronic unpredictable mild stress. International Journal of Applied and Basic Medical Research, 15(1), 25-31. https://doi.org/10.4103/IJABMR.IJABMR_330_24
- Michels, B., Franke, K., Weiglein, A., Sultani, H., Gerber, B., & Wessjohann, L. A. (2020). Rewarding compounds identified from the medicinal plant Rhodiola rosea. The Journal of Experimental Biology, 223(16), jeb223982. https://doi.org/10.1242/JEB.223982
- Mikulska, P., Malinowska, M., Ignacyk, M., Szustowski, P., Nowak, J., Pesta, K., Szeląg, M., Szklanny, D., Judasz, E., Kaczmarek, G., Ejiohuo, O. P., Paczkowska-Walendowska, M., Gościniak, A., & Cielecka-Piontek, J. (2023). Ashwagandha (Withania somnifera)—Current research on the health-promoting activities: a narrative review. Pharmaceutics, 15(4), 1057. https://doi.org/10.3390/PHARMACEUTICS15041057
- Mishra, D. N., & Kumar, M. (2024). Shoden promotes relief from stress and anxiety: a randomized, double-blind, placebo-controlled study on healthy subjects with high stress levels. Heliyon, 10(17), e36885. https://doi.org/10.1016/J.HELIYON.2024.E36885
- Mishra, S. K., Venkatachalapathy, B. A., & Khanli, H. M. (2017). Safety and efficacy of Ashwagandha (Withania somnifera). En G. Brahmachari (ed.), Neuroprotective natural products: clinical aspects and mode of action
- (pp. 313–319). Wiley. https://doi.org/10.1002/9783527803781
- Mohanan, P., Subramaniyam, S., Mathiyalagan, R., & Yang, D. C. (2018). Molecular signaling of ginsenosides Rb1, Rg1, and Rg3 and their mode of actions. Journal of Ginseng Research, 42(2), 123–132.
- https://doi.org/10.1016/J.JGR.2017.01.008
- Mohanan, P., Yang, T. J., & Song, Y. H. (2023). Genes and regulatory mechanisms for ginsenoside biosynthesis. Journal of Plant Biology, 66(1), 87–97. https://doi.org/10.1007/S12374-023-09384-7
- Mohsin, M. M., Hanif, M. A., Ayub, M. A., & Dharmadasa, R. M. (2023). Ginseng. En Medicinal Plants of South Asia: Novel Sources for Drug Discovery (pp. 331–340). Elseviere. https://doi.org/10.1016/B978-0-08-102659-5.00025-2
- Morshed, M. N., Ahn, J. C., Mathiyalagan, R., Rupa, E. J., Akter, R., Karim, M. R., Jung, D. H., Yang, D. U., Yang, D. C., & Jung, S. K. (2023). Antioxidant activity of panax ginseng to regulate ROS in various chronic diseases. Applied Sciences (Switzerland), 13(5), 2893. https://doi.org/10.3390/APP13052893
- Mukherjee, P. K., Banerjee, S., Biswas, S., Das, B., Kar, A., & Katiyar, C. K. (2021). Withania somnifera (L.) Dunal - Modern perspectives of an ancient Rasayana from Ayurveda. Journal of Ethnopharmacology, 264, 113157. https://doi.org/10.1016/j.jep.2020.113157
- Murthy, S. V., Fathima, S. N., & Mote, R. (2022). Hydroalcoholic extract of Ashwagandha improves sleep by modulating GABA/Histamine receptors and EEG slow-wave pattern in in vitro - in vivo experimental models. Preventive Nutrition and Food Science, 27(1), 108-120. https://doi.org/10.3746/PNF.2022.27.1.108
- Nan, F., Sun, G., Xie, W., Ye, T., Sun, X., Zhou, P., Dong, X., Sun, J., Sun, X., & Zhang, M. (2019). Ginsenoside Rb1 mitigates oxidative stress and apoptosis induced by methylglyoxal in SH-SY5Y cells via the PI3K/Akt pathway. Molecular and Cellular Probes, 48, 101469. https://doi.org/10.1016/J.MCP.2019.101469
- Narayanan, A. K., & Nagegowda, D. A. (2024). Biosynthesis of the triterpenoid withanolides in Withania somnifera. Current Opinion in Plant Biology, 81, 102576. https://doi.org/10.1016/J.PBI.2024.102576
- Noushad, S., Ahmed, S., Ansari, B., Mustafa, U. H., Saleem, Y., & Hazrat, H. (2021). Physiological biomarkers of chronic stress: a systematic review. International Journal of Health Sciences, 15(5), 46. https://pmc.ncbi.nlm.nih.gov/articles/PMC8434839/
- Obulesu, M. (2022). Effect of plant extracts against Alzheimer’s disease. Plant Extracts in Neurodegenerative Diseases, 1–15. https://doi.org/10.1016/B978-0-323-95762-5.00001-1
- Ozeer, F. Z., Nagandran, S., Wu, Y. S., Wong, L. S., Stephen, A., Lee, M. F., Kijsomporn, J., Guad, R. Mac, Batumalaie, K., Oyewusi, H. A., Verma, A., Yadav, E., Afzal, S., Sekar, M., Subramaniyan, V., Fuloria, N. K., Fuloria, S., & Sarker, M. M. R. (2024). A comprehensive review of phytochemicals of Withania somnifera (L.) Dunal (Solanaceae) as antiviral therapeutics. Discover Applied Sciences, 6(187), 1–20. https://doi.org/10.1007/S42452-024-05845-X
- Paik, D. J., & Lee, C. H. (2015). Review of cases of patient risk associated with ginseng abuse and misuse. Journal of Ginseng Research, 39(2), 89-93. https://doi.org/10.1016/J.JGR.2014.11.005
- Paik, S., Song, G. Y., & Jo, E. K. (2023). Ginsenosides for therapeutically targeting inflammation through modulation of oxidative stress. International Immunopharmacology, 121, 110461. https://doi.org/10.1016/J.INTIMP.2023.110461
- Panossian, A., & Brendler, T. (2020). The role of adaptogens in prophylaxis and treatment of viral respiratory infections. Pharmaceuticals, 13(9), 236. https://doi.org/10.3390/PH13090236
- Panossian, A., & Efferth, T. (2022). Network pharmacology of adaptogens in the assessment of their pleiotropic therapeutic activity. Pharmaceuticals, 15(9), 1051. https://doi.org/10.3390/PH15091051
- Panossian, A. G. (2013). Adaptogens in mental and behavioral disorders. Psychiatric Clinics of North America, 36(1), 49–64. https://doi.org/10.1016/J.PSC.2012.12.005
- Panossian, A., & Lemerond, T. (2025). Two sides of the same coin for health: adaptogenic botanicals as nutraceuticals for nutrition and pharmaceuticals in medicine. Pharmaceuticals, 18(9). https://doi.org/10.3390/PH18091346
- Park, K. C., Jin, H., Zheng, R., Kim, S., Lee, S. E., Kim, B. H., & Yim, S. V. (2019). Cognition enhancing effect of panax ginseng in Korean volunteers with mild cognitive impairment: a randomized, double-blind, placebo-controlled clinical trial. Translational and Clinical Pharmacology, 27(3), 92. https://doi.org/10.12793/TCP.2019.27.3.92
- Park, S. H., Chung, S., Chung, M. Y., Choi, H. K., Hwang, J. T., & Park, J. H. (2022). Effects of Panax ginseng on hyperglycemia, hypertension, and hyperlipidemia: a systematic review and meta-analysis. Journal of Ginseng Research, 46(2), 188–205. https://doi.org/10.1016/J.JGR.2021.10.002
- Park, S. K., Hyun, S. H., In, G., Park, C. K., Kwak, Y. S., Jang, Y. J., Kim, B., Kim, J. H., & Han, C. K. (2021). The antioxidant activities of Korean Red Ginseng (Panax ginseng) and ginsenosides: a systemic review through in vivo and clinical trials. Journal of Ginseng Research, 45(1), 41–47. https://doi.org/10.1016/J.JGR.2020.09.006
- Patnaik, N., & Patnaik, N. (2015). Role of Brahmi and Ashwagandha in anti-ageing. Journal of Biosciences and Medicines, 3(10), 102–104. https://doi.org/10.4236/JBM.2015.310014
- Peng, Z., Wu, W. W., & Yi, P. (2021). The efficacy of ginsenoside Rg3 combined with first-line chemotherapy in the treatment of advanced non-small cell lung cancer in China: a systematic review and meta-analysis of randomized clinical trials. Frontiers in Pharmacology, 11, 630825. https://doi.org/10.3389/FPHAR.2020.630825
- Piecuch, D., Sobota, W., Zwoliński, M., Piskorz, P., Hańczyk, E., Zemsta, K., & Kulesza, B. (2024). Ashwagandha (Withania somnifera) en la terapia del cáncer: actividades anticancerígenas y sus mecanismos. Calidad en el Deporte, 32, 56016. https://doi.org/10.12775/QS.2024.32.56016
- Pratte, M. A., Nanavati, K. B., Young, V., & Morley, C. P. (2014). An alternative treatment for anxiety: a systematic review of human trial results reported for the Ayurvedic Herb Ashwagandha (Withania somnifera). Journal of Alternative and Complementary Medicine, 20(12), 901–908. https://doi.org/10.1089/acm.2014.0177
- Priyanka, G., Anil Kumar, B., Lakshman, M., Manvitha, V., & Kala Kumar, B. (2020). Adaptogenic and immunomodulatory activity of Ashwagandha root extract: an experimental study in an equine model. Frontiers in Veterinary Science, 7, 541112. https://doi.org/10.3389/FVETS.2020.541112
- Pu, J., Yang, J., Xu, B., Zhang, Y., Zhang, W., Yang, D., Sun-Waterhouse, D., & Li, D. (2025). Targeting cancer epigenetics with PPD-type ginsenosides: a systematic review of mechanisms and therapeutic potential. Phytomedicine, 148, 157352. https://doi.org/10.1016/J.PHYMED.2025.157352
- Pushpakaran, A. M. K., Singh, J., Rasane, P., Kaur, S., Kaur, J., Kaur, J., Kumar, M., & Assouguem, A. (2025). Immunomodulatory effect of ashwagandha (Withania somnifera L. Dunal) and its impact on COVID-19. Foods and Raw Materials, 13(1), 46–57. https://doi.org/10.21603/2308-4057-2025-1-622
- Radad, K., Moldzio, R., & Rausch, W. D. (2010). Ginsenosides and their CNS targets. CNS Neuroscience & Therapeutics, 17(6), 761-768. https://doi.org/10.1111/J.1755-5949.2010.00208.X
- Rakha, A., Ramzan, Z., Umar, N., Rasheed, H., Fatima, A., Ahmed, Z., Kieliszek, M., & Aadil, R. M. (2023). The role of Ashwagandha in metabolic syndrome: a review of traditional knowledge and recent research findings. Journal of Biological Regulators and Homeostatic Agents, 37(10), 5091–5103. https://doi.org/10.23812/J.BIOL.REGUL.HOMEOST.AGENTS.20233710.494
- Ramapalaniappan, A., Loganathan, V., Morde, A., Padigaru, M., Patni, P., Joshua, L., & Thomas, J. V. (2025). Superior bioavailability of a novel 1.5% ashwagandha formulation (ZenrootTM): a randomized, double-blind, single-dose, comparative, oral bioavailability study in healthy adults. Advances in Therapy, 42(10), 4964-4976. https://doi.org/10.1007/S12325-025-03292-7
- Ramona, J., Ioana, J., Nicolae-Alexandru, C., Ovidiu, M., & Răzvan-Titus, P. (2024). Relationship between Ginseng, hypothalamic pituitary adrenal axis and Cortisol: a PubMed approach. Health, Sports & Rehabilitation Medicine, 25(1), 37–40. https://doi.org/10.26659/PM3.2024.25.1.37
- Ran, X., Dou, D., Chen, H., & Ren, G. (2022). The correlations of adverse effect and tonifying effect of ginseng medicines. Journal of Ethnopharmacology, 291, 115113. https://doi.org/10.1016/j.jep.2022.115113
- Ratan, Z. A., Haidere, M. F., Hong, Y. H., Park, S. H., Lee, J. O., Lee, J., & Cho, J. Y. (2020). Pharmacological potential of ginseng and its major component ginsenosides. Journal of Ginseng Research, 45(2), 199-210. https://doi.org/10.1016/J.JGR.2020.02.004
- Ratan, Z. A., Youn, S. H., Kwak, Y. S., Han, C. K., Haidere, M. F., Kim, J. K., Min, H., Jung, Y. J., Hosseinzadeh, H., Hyun, S. H., & Cho, J. Y. (2020). Adaptogenic effects of Panax ginseng on modulation of immune functions. Journal of Ginseng Research, 45(1), 32-40. https://doi.org/10.1016/J.JGR.2020.09.004
- Razgonova, M. P., Veselov, V. V., Zakharenko, A. M., Golokhvast, K. S., Nosyrev, A. E., Cravotto, G., Tsatsakis, A., & Spandidos, D. A. (2019). Panax ginseng components and the pathogenesis of Alzheimer’s disease. Molecular Medicine Reports, 19(4), 2975-2998. https://doi.org/10.3892/MMR.2019.9972
- Rodthongdee, K., Watanapa, W. B., Ruamyod, K., Semprasert, N., Nambundit, P., Kooptiwut, S., & Boontaveekul, L. (2025). Ginsenoside Re increases human coronary artery endothelial SKCa current and nitric oxide release via glucocorticoid receptor-PI3K-Akt/PKB pathway. Journal of Ginseng Research. https://doi.org/10.1016/J.JGR.2025.04.008
- Ross, S. M. (2014). Rhodiola rosea (SHR-5), Part I: a proprietary root extract of Rhodiola rosea is found to be effective in the treatment of stress-related fatigue. Holistic Nursing Practice, 28(2), 149–154.
- https://doi.org/10.1097/HNP.0000000000000014
- Ross, S. M. (2023). The clinical efficacy of Rhodiola rosea L. in managing stress-induced conditions. Holistic Nursing Practice, 37(4), 233–235. https://doi.org/10.1097/HNP.0000000000000597
- Ryu, H. J., Jung, C. J., & Beik, G. Y. (2020). Antioxidant activities of flower, berry and leaf of Panax ginseng C. A. Meyer. Korean Journal of Food Science and Technology, 52(4), 342–349. https://www.dbpia.co.kr/Journal/articleDetail?nodeId=NODE09871453
- Sadeghian, M., Rahmani, S., Zendehdel, M., Hosseini, S. A., & Zare Javid, A. (2020). Ginseng and cancer-related fatigue: a systematic review of clinical trials. Nutrition and Cancer, 73(8), 1270–1281. https://doi.org/10.1080/01635581.2020.1795691
- Sala, F., Mulet, J., Choi, S., Jung, S. Y., Nah, S. Y., Rhim, H., Valor, L. M., Criado, M., & Sala, S. (2002). Effects of ginsenoside Rg2 on human neuronal nicotinic acetylcholine receptors. Journal of Pharmacology and Experimental Therapeutics, 301(3), 1052–1059. https://doi.org/10.1124/jpet.301.3.1052
- Saleem, S., Muhammad, G., Hussain, M. A., Altaf, M., & Abbas Bukhari, S. N. (2020). Withania somnifera L.: insights into the phytochemical profile, therapeutic potential, clinical trials, and future prospective. Iranian Journal of Basic Medical Sciences, 23(12), 1501-1526. https://doi.org/10.22038/IJBMS.2020.44254.10378
- Salve, J., Kale, S., Prajapati, B. L., Sparavigna, A., Savant, M., Ademola, J., & Langade, D. (2025). Safety of 12-Months administration of Ashwagandha (Withania somnifera) standardized root extract in healthy adults: a prospective, observational study. Phytotherapy Research, 1–11. https://doi.org/10.1002/PTR.70096
- Salve, J., Pate, S., Debnath, K., & Langade, D. (2019). Adaptogenic and anxiolytic effects of ashwagandha root extract in healthy adults: a double-blind, randomized, placebo-controlled clinical study. Cureus, 11(12), e6466. https://doi.org/10.7759/cureus.6466
- Sánchez, I. A., Cuchimba, J. A., Pineda, M. C., Argüello, Y. P., Kočí, J., Kreider, R. B., Petro, J. L., & Bonilla, D. A. (2023). Adaptogens on depression-related outcomes: a systematic integrative review and rationale of synergism with physical activity. International Journal of Environmental Research and Public Health, 20(7), 5298. https://doi.org/10.3390/IJERPH20075298
- Sangiovanni, E., Brivio, P., Dell’Agli, M., & Calabrese, F. (2017). Botanicals as modulators of neuroplasticity: focus on BDNF. Neural Plasticity, 2017(1), 5965371. https://doi.org/10.1155/2017/5965371
- Searels, J. M., Keen, K. D., Horton, J. L., Clarke, H. D., & Ward, J. R. (2013). Comparing ginsenoside production in leaves and roots of wild American ginseng (Panax quinquefolius). American Journal of Plant Sciences, 4(6), 1252–1259. https://doi.org/10.4236/AJPS.2013.46154
- Seki, H., Tamura, K., & Muranaka, T. (2015). P450s and UGTs: key players in the structural diversity of triterpenoid saponins. Plant and Cell Physiology, 56(8), 1463–1471. https://doi.org/10.1093/PCP/PCV062
- Sengupta, P., Agarwal, A., Pogrebetskaya, M., Roychoudhury, S., Durairajanayagam, D., & Henkel, R. (2018). Role of Withania somnifera (Ashwagandha) in the management of male infertility. Reproductive BioMedicine Online, 36(3), 311–326. https://doi.org/10.1016/J.RBMO.2017.11.007
- Shao, J. W., Jiang, J. L., Zou, J. J., Yang, M. Y., Chen, F. M., Zhang, Y. J., & Jia, L. (2020). Therapeutic potential of ginsenosides on diabetes: from hypoglycemic mechanism to clinical trials. Journal of Functional Foods, 64, 103630. https://doi.org/10.1016/J.JFF.2019.103630
- Sharan, P., & Vellapandian, C. (2024). Hypothalamic-Pituitary-Adrenal (HPA) Axis: unveiling the potential mechanisms involved in stress-induced Alzheimer’s disease and depression. Cureus, 16(8), e67595. https://doi.org/10.7759/CUREUS.67595
- Shim, Y., Lee, Y. S., Kim, Y., Lee, S. E., Suh, C., Ha, E., Joo, Y., Lee, H., Lee, S., Shin, W. C., Yoon, S., Lyoo, I. K., & Lee, D. Y. (2025). Effects of white ginseng on reducing stress and tension by enhancing default mode network connectivity: a randomized, double-blinded placebo-controlled clinical trial. Journal of Ginseng Research, 49(6), 725-733. https://doi.org/10.1016/J.JGR.2025.08.004
- Shin, M. S., Lee, Y. J., Cho, I. H., & Yang, H. J. (2024). Brain plasticity and ginseng. Journal of Ginseng Research, 48(3), 286-297. https://doi.org/10.1016/J.JGR.2024.03.007
- Shin, M. S., Song, J. H., Choi, P., Lee, J. H., Kim, S. Y., Shin, K. S., Ham, J., & Kang, K. S. (2018). Stimulation of innate immune function by panax ginseng after heat processing. Journal of Agricultural and Food Chemistry, 66(18), 4652–4659. https://doi.org/10.1021/ACS.JAFC.8B00152
- Singh, A. A., Katiyar, S., & Song, M. (2025). Phytochemicals targeting BDNF signaling for treating neurological disorders. Brain Sciences, 15(3), 252. https://doi.org/10.3390/BRAINSCI15030252
- Singh, M., Bhutani, S., Dinkar, N., Mishra, A., Perveen, K., Alfagham, A. T., Khanam, M. N., Bhatt, S. C., & Suyal, D. C. (2023). Estimating the production of withaferin A and withanolide A in Withania somnifera (L.) dunal using aquaponics for sustainable development in hill agriculture. Frontiers in Plant Science, 14, 1215592. https://doi.org/10.3389/FPLS.2023.1215592
- Singh, M., Kuldeep, Chaudhary, P., Bhasin, S., Mehra, A., & Bhutani, S. (2024). Phytochemicals of Withania somnifera and their perspective on plant defense against stress. En R. Lone, S. Khan, & A. Mohamed Al-Sadi (eds.), Plant phenolics in biotic stress management (pp. 275–304). https://doi.org/10.1007/978-981-99-3334-1_11
- Singh, N., Bhalla, M., de Jager, P., & Gilca, M. (2011). An overview on ashwagandha: a rasayana (rejuvenator) of ayurveda. African Journal of Traditional, Complementary, and Alternative Medicines, 8(5), 208-213. https://doi.org/10.4314/AJTCAM.V8I5S.9
- Smith, S. J., Lopresti, A. L., & Fairchild, T. J. (2023). Exploring the efficacy and safety of a novel standardized ashwagandha (Withania somnifera) root extract (Witholytin®) in adults experiencing high stress and fatigue in a randomized, double-blind, placebo-controlled trial. Journal of Psychopharmacology, 37(11), 1091–1104. https://doi.org/10.1177/02698811231200023
- Song, Y., Chen, C., & Li, W. (2024). Ginsenoside Rb1 in cardiovascular and cerebrovascular diseases: a review of therapeutic potentials and molecular mechanisms. Chinese Herbal Medicines, 16(4), 489–504. https://doi.org/10.1016/J.CHMED.2024.09.006
- Speers, A. B., Cabey, K. A., Soumyanath, A., & Wright, K. M. (2021). Effects of Withania somnifera (Ashwagandha) on stress and the stress-related neuropsychiatric disorders anxiety, depression, and insomnia. Current Neuropharmacology, 19(9), 1468–1495. https://doi.org/10.2174/1570159X19666210712151556
- Speers, A. B., Lozano-Ortiz, A., & Soumyanath, A. (2024). Quantifying withanolides in plasma: pharmacokinetic studies and analytical methods. Nutrients, 16(22), 3836. https://doi.org/10.3390/NU16223836
- Sprengel, M., Laskowski, R., & Jost, Z. (2025). Withania somnifera (Ashwagandha) supplementation: a review of its mechanisms, health benefits, and role in sports performance. Nutrition & Metabolism, 22(9), 1–8. https://doi.org/10.1186/S12986-025-00902-7
- Stephen, A., Tune, B. X. J., Wu, Y. S., Batumalaie, K., Sekar, M., Sarker, Md. M. R., Subramaniyan, V., Fuloria, N. K., Fuloria, S., & Gopinath, S. C. B. (2025). Withanone as an emerging anticancer agent and understanding its molecular mechanisms: experimental and computational evidence. Current Cancer Drug Targets, 25(6), 574–585. https://doi.org/10.2174/0115680096290673240223043650
- Stojcheva, E. I., & Quintela, J. C. (2022). The effectiveness of Rhodiola rosea L. preparations in alleviating various aspects of life-stress symptoms and stress-induced conditions—encouraging clinical evidence. Molecules, 27(12), 3902. https://doi.org/10.3390/MOLECULES27123902
- Sun, M., Ye, Y., Xiao, L., Duan, X., Zhang, Y., & Zhang, H. (2017). Anticancer effects of ginsenoside Rg3 (Review). International Journal of Molecular Medicine, 39(3), 507–518. https://doi.org/10.3892/IJMM.2017.2857
- Sun, Y., Fu, X., Qu, Y., Chen, L., Liu, X., He, Z., Xu, J., Yang, J., Ma, W., Li, J., Guo, Q., & Zhang, Y. (2023). Characterization of ginsenosides from the root of panax ginseng by integrating untargeted metabolites using UPLC-Triple TOF-MS. Molecules, 28(5), 2068. https://doi.org/10.3390/MOLECULES28052068
- Sutopo, N. C., Qomaladewi, N. P., Lee, H. W., Lee, M. S., Kim, J. H., & Cho, J. Y. (2025). Comprehensive understanding and underlying molecular mechanisms of the adaptogenic effects of Panax ginseng. Journal of Ginseng Research, 49(4), 356-365. https://doi.org/10.1016/J.JGR.2025.03.013
- Syed, R. U., Hadi, M. A., Almarir, A. M., Alahmari, A. M., Alremthi, Y. H., Alsagri, A. A. A., Laimooniah, D., & Break, M. K. B. (2024). Rhodiola rosea L. extract ameliorates ethanol-induced gastric ulcer in rats by alleviating oxidative stress and inflammation via NF-κB pathway inhibition. Current Plant Biology, 40, 100421. https://doi.org/10.1016/j.cpb.2024.100421
- Tallon, M. J., Koturbash, I., & Blum, J. L. (2025). A systematic and ethnobotanical review of ashwagandha’s (Withania Somnifera) teratogenic and abortifacient potentials. Phytotherapy Research. https://doi.org/10.1002/PTR.70079
- Tandon, N., & Yadav, S. S. (2020). Safety and clinical effectiveness of Withania Somnifera (Linn.) Dunal root in human ailments. Journal of Ethnopharmacology, 255, 112768. https://doi.org/10.1016/j.jep.2020.112768
- Tang, K., Qin, W., Wei, R., Jiang, Y., Fan, L., Wang, Z., & Tan, N. (2022). Ginsenoside Rd ameliorates high glucose-induced retinal endothelial injury through AMPK-STRT1 interdependence. Pharmacological Research, 179, 106123. https://doi.org/10.1016/j.phrs.2022.106123
- Tang, M. M., Zhao, S. T., Li, R. Q., & Hou, W. (2023). Therapeutic mechanisms of ginseng in coronary heart disease. Frontiers in Pharmacology, 14, 1271029. https://doi.org/10.3389/FPHAR.2023.1271029
- Tang, P., Liu, S., Zhang, J., Ai, Z., Hu, Y., Cui, L., Zou, H., Li, X., Wang, Y., Nan, B., & Wang, Y. (2024). Ginsenosides as dietary supplements with immunomodulatory effects: a review. Applied Biological Chemistry, 67(1), 1–17. https://doi.org/10.1186/S13765-024-00881-Y
- Tharakan, A., Shukla, H., Benny, I. R., Tharakan, M., George, L., & Koshy, S. (2021). Immunomodulatory effect of withania somnifera (Ashwagandha) extract—A randomized, double-blind, placebo controlled trial with an open label extension on healthy participants. Journal of Clinical Medicine, 10(16), 3644. https://doi.org/10.3390/JCM10163644
- Tian, Z. F., Hu, R. Y., Wang, Z., Wang, Y. J., & Li, W. (2024). Molecular mechanisms behind the inhibitory effects of ginsenoside Rg3 on hepatic fibrosis: a review. Archives of Toxicology, 99(2), 541–561. https://doi.org/10.1007/S00204-024-03941-W
- Tinsley, G. M., Jagim, A. R., Potter, G. D. M., Garner, D., & Galpin, A. J. (2024). Rhodiola rosea as an adaptogen to enhance exercise performance: a review of the literature. British Journal of Nutrition, 131(3), 461–473. https://doi.org/10.1017/S0007114523001988
- Todorova, V., Ivanov, K., Delattre, C., Nalbantova, V., Karcheva-Bahchevanska, D., & Ivanova, S. (2021). Plant adaptogens-history and future perspectives. Nutrients, 13(8), 2861. https://doi.org/10.3390/NU13082861
- Tóth-Mészáros, A., Garmaa, G., Hegyi, P., Bánvölgyi, A., Fenyves, B., Fehérvári, P., Harnos, A., Gergő, D., Nguyen Do To, U., & Csupor, D. (2023). The effect of adaptogenic plants on stress: a systematic review and meta-analysis. Journal of Functional Foods, 108, 105695. https://doi.org/10.1016/J.JFF.2023.105695
- van Diermen, D., Marston, A., Bravo, J., Reist, M., Carrupt, P. A., & Hostettmann, K. (2009). Monoamine oxidase inhibition by Rhodiola rosea L. roots. Journal of Ethnopharmacology, 122(2), 397–401. https://doi.org/10.1016/J.JEP.2009.01.007
- Verma, N., Gupta, S. K., Tiwari, S., & Mishra, A. K. (2021). Safety of ashwagandha root extract: a randomized, placebo-controlled, study in healthy volunteers. Complementary Therapies in Medicine, 57, 102642. https://doi.org/10.1016/j.ctim.2020.102642
- Vittal, M., & Vinciguerra, M. (2025). Enhancing healthspan with Ashwagandha (Withania somnifera): a comprehensive review of its multifaceted geroprotective benefits. Biogerontology, 26(5), 1–20. https://doi.org/10.1007/S10522-025-10320-0
- Wang, C. H., Safwan, S., Cheng, M. C., Liao, T. Y., Cheng, L. C., Chen, T. A., Kuo, Y. H., Lin, Y. F., & Lee, C. K. (2020). Protective evaluation of compounds extracted from root of rhodiola rosea l. against methylglyoxal-induced toxicity in a neuronal cell line. Molecules, 25(12), 2801. https://doi.org/10.3390/MOLECULES25122801
- Wang, I. L., Su, Y., Zhang, L., Tang, M., & Chen, Y. M. (2025). Combined Rhodiola rosea and eccentric training boost endurance performance and lower-limb reactive strength in recreationally active women. Frontiers in Physiology, 16, 1663086. https://doi.org/10.3389/FPHYS.2025.1663086
- Wang, Q., Wei, L., Chen, G., & Chen, Q. (2025). Ginsenoside Rg1 in Parkinson’s disease: from basic research to clinical applications. Frontiers in Pharmacology, 16, 1490480. https://doi.org/10.3389/FPHAR.2025.1490480
- Wang, S., Feng, Y., Zheng, L., He, P., Tan, J., Cai, J., Wu, M., & Ye, X. (2023). Rosavin: research advances in extraction and synthesis, pharmacological activities and therapeutic effects on diseases of the characteristic active ingredients of Rhodiola rosea L. Molecules, 28(21), 7412. https://doi.org/10.3390/MOLECULES28217412
- Wang, W., Rayburn, E. R., Zhao, Y., Wang, H., & Zhang, R. (2009). Novel Ginsenosides 25-OH-PPD and 25-OCH3-PPD as experimental therapy for pancreatic cancer: anticancer activity and mechanisms of action. Cancer Letters, 278(2), 241-248. https://doi.org/10.1016/J.CANLET.2009.01.005
- Wang, X., Wang, R., Qiao, Y., & Li, Y. (2022). Progress on the efficacy and mechanism of action of panax ginseng monomer saponins treat toxicity. Frontiers in Pharmacology, 13, 1022266. https://doi.org/10.3389/FPHAR.2022.1022266
- Wang, X., Yang, X., Gao, Z., Zeng, J., & Liu, Y. (2025). The effect of Rhodiola rosea supplementation on endurance performance and related biomarkers: a systematic review and meta-analysis. Frontiers in Nutrition, 12, 1645346. https://doi.org/10.3389/FNUT.2025.1645346
- Wang, Y., Li, G., Chen, T., Wu, W., Yan, Z., & Li, X. (2023). Anticancer effect and molecular mechanism of ginsenoside Rg3 in various cancer types. Intelligent Pharmacy, 1(2), 52–63. https://doi.org/10.1016/J.IPHA.2023.04.012
- Wegener, T., Edwards, D., & Kasper, S. (2023). The potential role of Rhodiola rosea L. extract WS® 1375 for patients with post-COVID-19 fatigue. Healthbook TIMES Das Schweizer Ärztejournal Journal Des Médecins Suisses, 8(1), 56–61. https://doi.org/10.36000/HBT.2023.09.001
- Wiciński, M., Fajkiel-Madajczyk, A., Sławatycki, J., Szambelan, M., Szyperski, P., Wojciechowski, P., Wójcicki, J., & Gawryjołek, M. (2025). Ashwagandha (Withania somnifera) and its effects on well-being-a review. Nutrients, 17(13), 2143. https://doi.org/10.3390/NU17132143
- Wróbel-Biedrawa, D., & Podolak, I. (2024). Anti-Neuroinflammatory Effects of Adaptogens: A Mini-Review. Molecules, 29(4), 866. https://doi.org/10.3390/MOLECULES29040866
- Wu, J., Yang, Y., Wan, Y., Xia, J., Xu, J. F., Zhang, L., Liu, D., Chen, L., Tang, F., Ao, H., & Peng, C. (2022). New insights into the role and mechanisms of ginsenoside Rg1 in the management of Alzheimer’s disease. Biomedicine & Pharmacotherapy, 152, 113207. https://doi.org/10.1016/J.BIOPHA.2022.113207
- Wu, L., Bai, L., Dai, W., Wu, Y., Xi, P., Zhang, J., & Zheng, L. (2024). Ginsenoside Rg3: a review of its anticancer mechanisms and potential therapeutic applications. Current Topics in Medicinal Chemistry, 24(10), 869–884. https://doi.org/10.2174/0115680266283661240226052054
- Xia, G. Y., Cao, S. J., Chen, L. X., & Qiu, F. (2022). Natural withanolides, an update. Natural Product Reports, 39(4), 784–813. https://doi.org/10.1039/D1NP00055A
- Xia, N., Li, J., Wang, H., Wang, J., & Wang, Y. (2016). Schisandra chinensis and Rhodiola rosea exert an anti-stress effect on the HPA axis and reduce hypothalamic c-Fos expression in rats subjected to repeated stress. Experimental and Therapeutic Medicine, 11(1), 353–359. https://doi.org/10.3892/ETM.2015.2882
- Xiao, H., Zhang, Y., Zhang, B., Wu, J., & Li, X. (2025). Ginsenoside Rg3 exerts anticancer effects in lung cancer through metabolite Histon H3. American Journal of Translational Research, 17(5), 3994. https://doi.org/10.62347/YJZW4664
- Xiaodan, S., & Ying, C. (2022). Role of ginsenoside Rh2 in tumor therapy and tumor microenvironment immunomodulation. Biomedicine & Pharmacotherapy, 156, 113912. https://doi.org/10.1016/J.BIOPHA.2022.113912
- Xiu, Y., Li, X., Sun, X., Xiao, D., Miao, R., Zhao, H., & Liu, S. (2019). Simultaneous determination and difference evaluation of 14 ginsenosides in Panax ginseng roots cultivated in different areas and ages by high-performance liquid chromatography coupled with triple quadrupole mass spectrometer in the multiple reaction–monitoring mode combined with multivariate statistical analysis. Journal of Ginseng Research, 43(4), 508-516. https://doi.org/10.1016/J.JGR.2017.12.001
- Xu, W., Yang, T., Zhang, J., Li, H., & Guo, M. (2024). Rhodiola rosea: a review in the context of PPPM approach. The EPMA Journal, 15(2), 233-259. https://doi.org/10.1007/S13167-024-00367-3
- Xu, X., Qu, W., Jia, Z., Han, T., Liu, M., Bai, Y., Wang, M., Lin, R., Hua, Q., & Li, X. (2021). Effect of cultivation ages on anti-inflammatory activity of a new type of red ginseng. Biomedicine & Pharmacotherapy, 136, 111280. https://doi.org/10.1016/J.BIOPHA.2021.111280
- Xue, Y., Zhang, R., Li, T., Deng, Q., Luo, W., Chang, R., Zeng, D., Tan, J., Sun, T., Liu, Y. G., Xiang, Y., Zhu, Q., & Chai, N. (2025). Sustainable production of ginsenosides: advances in biosynthesis and metabolic engineering. Plants, 14(18), 2821. https://doi.org/10.3390/PLANTS14182821
- Yang, L., Chen, X., & Gao, Y. (2022). Efficacy of different concentrations of withanolides in ashwagandha supplements for insomnia and enhancing energy level. Current Developments in Nutrition, 6(1), 881. https://doi.org/10.1093/CDN/NZAC067.001
- Yang, Q., Xiong, C., Zhang, J., Ming, Y., Zhang, S., Wang, L., Wang, H., Xu, R., & Wang, B. (2024). Chemical and transcriptomic analyses provide new insights into key genes for ginsenoside biosynthesis in the Rhizome of Panax japonicus C. A. Meyer. Molecules, 29(20), 4936. https://doi.org/10.3390/MOLECULES29204936/S1
- Yang, Y., Nan, Y., Du, Y., Liu, W., Ning, N., Chen, G., Gu, Q., & Yuan, L. (2024). Ginsenosides in cancer: proliferation, metastasis, and drug resistance. Biomedicine & Pharmacotherapy, 177, 117049. https://doi.org/10.1016/J.BIOPHA.2024.117049
- Yao, F., Li, X., Sun, J., Cao, X., Liu, M., Li, Y., & Liu, Y. (2021). Thermal transformation of polar into less-polar ginsenosides through demalonylation and deglycosylation in extracts from ginseng pulp. Scientific Reports, 11(1), 1513. https://doi.org/10.1038/S41598-021-81079-W
- Yao, W., & Guan, Y. (2022). Ginsenosides in cancer: a focus on the regulation of cell metabolism. Biomedicine & Pharmacotherapy, 156, 113756. https://doi.org/10.1016/J.BIOPHA.2022.113756
- Yaribeygi, H., Panahi, Y., Sahraei, H., Johnston, T. P., & Sahebkar, A. (2017). The impact of stress on body function: a review. EXCLI Journal, 16, 1057–1072. https://doi.org/10.17179/EXCLI2017-480
- Ye, X. W., Li, C. S., Zhang, H. X., Li, Q., Cheng, S. Q., Wen, J., Wang, X., Ren, H. M., Xia, L. J., Wang, X. X., Xu, X. F., & Li, X. R. (2023). Saponins of ginseng products: a review of their transformation in processing. Frontiers in Pharmacology, 14, 1177819. https://doi.org/10.3389/FPHAR.2023.1177819
- Ye, Z., Wang, S., Wan, Z., Huang, B., & Guo, J. (2025). Targeting NADPH oxidase-driven oxidative stress in diabetic cardiomyopathy: mechanisms and therapeutic perspectives. Frontiers in Pharmacology, 16, 1610429. https://doi.org/10.3389/FPHAR.2025.1610429
- Yi, Y. S. (2024). Pharmacological potential of ginseng and ginsenosides in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis. Journal of Ginseng Research, 48(2), 122–128. https://doi.org/10.1016/J.JGR.2023.11.003
- You, L., Cha, S., Kim, M. Y., & Cho, J. Y. (2022). Ginsenosides are active ingredients in Panax ginseng with immunomodulatory properties from cellular to organismal levels. Journal of Ginseng Research, 46(6),
- 711–721. https://doi.org/10.1016/J.JGR.2021.12.007
- Yuan, W., Wang, Q., Pei, W., Li, S., Wang, T., Song, H., Teng, D., Kang, T., & Zhang, H. (2024). Age-induced changes in ginsenoside accumulation and primary metabolic characteristics of Panax Ginseng in transplantation mode. Journal of Ginseng Research, 48(1), 103–111. https://doi.org/10.1016/J.JGR.2023.09.003
- Yun, Y. B., Kwon, H. Y., & Um, Y. (2024). Changes in growth characteristics and ginsenoside contents of wild-simulated ginseng with different harvest times in South Korea. Applied Biological Chemistry, 67(66), 1–10. https://doi.org/10.1186/S13765-024-00920-8
- Yusuf, N., Nasti, T. H., Ahmad, I., Chowdhury, S., Mohiuddin, H., Xu, H., Athar, M., Timares, L., & Elmets, C. A. (2015). In vivo suppression of heat shock protein (HSP)27 and HSP70 accelerates DMBA-induced skin carcinogenesis by inducing antigenic unresponsiveness to the initiating carcinogenic chemical. The Journal of Immunology, 194(10), 4796–4803. https://doi.org/10.4049/JIMMUNOL.1402804
- Zakharenko, A. M., Razgonova, M. P., Pikula, K. S., & Golokhvast, K. S. (2021). Simultaneous determination of 78 compounds of Rhodiola rosea extract by supercritical CO2-extraction and HPLC-ESI-MS/MS spectrometry. Biochemistry Research International, 2021(1), 9957490. https://doi.org/10.1155/2021/9957490
- Zhai, Z., & Gao, Y. (2025). Protective effects of ginsenosides in cerebral small vessel disease: cellular and molecular mechanisms. Journal of Ginseng Research, 49(6), 640-651. https://doi.org/10.1016/J.JGR.2025.08.007
- Zhang, L., Yin, H., Xie, Y., Zhang, Y., Dong, F., Wu, K., Yang, L., & Lv, H. (2024). Exploring the anti oxidative mechanisms of Rhodiola rosea in ameliorating myocardial fibrosis through network pharmacology and in vitro experiments. Molecular Medicine Reports, 30(6), 1-13. https://doi.org/10.3892/MMR.2024.13338
- Zhang, Z., Yang, Y., Xu, Y., Liu, Y., Li, H., & Chen, L. (2023). Molecular targets and mechanisms of anti-cancer effects of withanolides. Chemico-Biological Interactions, 384, 110698. https://doi.org/10.1016/J.CBI.2023.110698
- Zhao, L., Zhang, T., & Zhang, K. (2024). Pharmacological effects of ginseng and ginsenosides on intestinal inflammation and the immune system. Frontiers in Immunology, 15, 1353614. https://doi.org/10.3389/FIMMU.2024.1353614
- Zheng, S., Zheng, H., Zhang, R., Piao, X., Hu, J., Zhu, Y., & Wang, Y. (2022). Immunomodulatory effect of Ginsenoside Rb2 against Cyclophosphamide-induced immunosuppression in mice. Frontiers in Pharmacology, 13, 927087. https://doi.org/10.3389/FPHAR.2022.927087
- Zhong, Y., Chen, Y., Pan, Z., Tang, K., Zhong, G., Guo, J., Cui, T., Li, T., Duan, S., Yang, X., Gao, Y., Wang, Q., & Zhang, D. (2022). Ginsenoside Rc, as an FXR activator, alleviates acetaminophen-induced hepatotoxicity via relieving inflammation and oxidative stress. Frontiers in Pharmacology, 13, 1027731. https://doi.org/10.3389/FPHAR.2022.1027731
- Zhou, B., Wu, L., Liu, D., Xie, X., Zhang, X., Liu, Y., Hao, B., Shi, G., Yu, S., Zheng, Z., Lin, L., Wang, M., & Qian, X. (2025). Ginsenoside Rb1 attenuates age-associated cognitive impairment by modulating oxidative stress and the SIRT1/eNOS/NO axis. Journal of Ginseng Research, 49(6), 683-691. https://doi.org/10.1016/J.JGR.2025.06.002
- Zhou, G., Wang, C. Z., Mohammadi, S., Sawadogo, W. R., Ma, Q., & Yuan, C. S. (2023). Pharmacological effects of ginseng: multiple constituents and multiple actions on humans. The American Journal of Chinese Medicine, 51(5), 1085–1104. https://doi.org/10.1142/S0192415X23500507
- Zhou, P., Xie, W., He, S., Sun, Y., Meng, X., Sun, G., & Sun, X. (2019). Ginsenoside Rb1 as an anti-diabetic agent and its underlying mechanism analysis. Cells, 8(3), 204. https://doi.org/10.3390/CELLS8030204
- Zhu, G., Wang, Y., Li, J., & Wang, J. (2015). Chronic treatment with ginsenoside Rg1 promotes memory and hippocampal long-term potentiation in middle-aged mice. Neuroscience, 292, 81–89. https://doi.org/10.1016/j.neuroscience.2015.02.031
- Zhu, Z., Li, R., Qin, W., Zhang, H., Cheng, Y., Chen, F., Chen, C., Chen, L., & Zhao, Y. (2021). Target engagement of ginsenosides in mild cognitive impairment using mass spectrometry-based drug affinity responsive target stability. Journal of Ginseng Research, 46(6), 750-758. https://doi.org/10.1016/J.JGR.2021.12.003
- Zhuang, S., Shi, F., Cannella, N., Ubaldi, M., Ciccocioppo, R., Li, H., & Qin, D. (2025). Pharmacological mechanism and drug research prospects of ginsenoside Rb1 as an antidepressant. Antioxidants 2025, 14(2), 238. https://doi.org/10.3390/ANTIOX14020238
- Zhuang, W., Yue, L., Dang, X., Chen, F., Gong, Y., Lin, X., & Luo, Y. (2019). Rosenroot (Rhodiola): potential applications in aging-related diseases. Aging and Disease, 10(1), 134-146. https://doi.org/10.14336/AD.2018.0511