Vol. 36 (2026): Volumen 36
Artículos de revisión

Adaptogens: nature, function, and main representatives

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  • Jorge Alejandro Sosa Gutiérrez,
  • Cristo Omar Puente Valenzuela,
  • Rolando Adair Facio Campos,
  • Edgar Héctor Olivas Calderón
Jorge Alejandro Sosa Gutiérrez
Universidad Juárez del Estado de Durango Facultad de Ciencias Químicas Gómez Palacio
Cristo Omar Puente Valenzuela
Universidad Juárez del Estado de Durango Facultad de Ciencias Biológicas Gómez Palacio
Rolando Adair Facio Campos
Universidad Juárez del Estado de Durango Facultad de Ciencias Químicas Gómez Palacio
Edgar Héctor Olivas Calderón
Universidad Juárez del Estado de Durango Facultad de Ciencias Químicas Gómez Palacio
DOI: https://doi.org/10.15174/au.2026.4743

Published 2026-03-25

How to Cite

Sosa Gutiérrez, J. A., Puente Valenzuela, C. O., Facio Campos, R. A., & Olivas Calderón, E. H. (2026). Adaptogens: nature, function, and main representatives. Acta Universitaria, 36, 1–34. https://doi.org/10.15174/au.2026.4743

Copyright (c) 2026 Jorge Alejandro Sosa Gutiérrez, Cristo Omar Puente Valenzuela, Rolando Adair Facio Campos, Edgar Héctor Olivas Calderón

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Abstract

Adaptogens are natural compounds, primarily of plant origin, that have attracted growing scientific interest due to their ability to enhance the body's nonspecific resistance to physical, mental, and environmental stress. They act by modulating the hypothalamic-pituitary-adrenal (HPA) axis and other neuroendocrine systems, promoting homeostasis without altering normal physiological functions. Recent research has documented beneficial effects of adaptogens such as Panax ginseng, Rhodiola rosea, and Withania somnifera in reducing stress, fatigue, and mood disorders, as well as in improving physical and cognitive performance. Despite empirical support from preclinical and clinical studies, challenges remain regarding the standardization of extracts, specific molecular mechanisms, and large-scale clinical validation. This paper reviews the most recent evidence on major adaptogens, their mechanisms of action, therapeutic applications, and future perspectives.

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References

  1. Abdelwahed, M. T., Hegazy, M. A., & Mohamed, E. H. (2023). Major biochemical constituents of Withania somnifera (ashwagandha) extract: a review of chemical analysis. Reviews in Analytical Chemistry, 42(1). https://doi.org/10.1515/REVAC-2022-0055
  2. Afewerky, H. K., Ayodeji, A. E., Tiamiyu, B. B., Orege, J. I., Okeke, E. S., Oyejobi, A. O., Ndip, P., & Adeyemi, S. B. (2021). Critical review of the Withania somnifera (L.) Dunal: ethnobotany, pharmacological efficacy, and commercialization significance in Africa. Bulletin of the National Research Centre, 45(1), 1–16. https://doi.org/10.1186/S42269-021-00635-6
  3. Agapouda, A., Grimm, A., Lejri, I., & Eckert, A. (2022). Rhodiola rosea extract counteracts stress in an adaptogenic response curve manner via elimination of ROS and induction of neurite outgrowth. Oxidative Medicine and Cellular Longevity, 2022(1), 5647599. https://doi.org/10.1155/2022/5647599
  4. Alanazi, H. H., & Elfaki, E. (2023). The immunomodulatory role of withania somnifera (L.) dunal in inflammatory diseases. Frontiers in Pharmacology, 14, 1084757. https://doi.org/10.3389/FPHAR.2023.1084757
  5. Al-Eisa, R. A. (2025). A review on selected pharmacological and phytochemical activities of Ashwagandha (Withania somnifera). Egyptian Journal of Veterinary Sciences, 0(0), 1–23. https://doi.org/10.21608/EJVS.2025.311925.2328
  6. Aminifard, T., Razavi, B. M., & Hosseinzadeh, H. (2021). The effects of ginseng on the metabolic syndrome: an updated review. Food Science & Nutrition, 9(9), 5293-5311. https://doi.org/10.1002/FSN3.2475
  7. An, L., Yu, Y., He, L., Xiao, X., & Li, P. (2024). Ginsenoside Rb1 deters cell proliferation, induces apoptosis, alleviates oxidative stress, and antimetastasis in oral squamous carcinoma cells. Applied Biochemistry and Biotechnology, 196(11), 7642–7656. https://doi.org/10.1007/S12010-024-04880-Z
  8. Anghelescu, I. G., Edwards, D., Seifritz, E., & Kasper, S. (2018). Stress management and the role of Rhodiola rosea: a review. International Journal of Psychiatry in Clinical Practice, 22(4), 242–252. https://doi.org/10.1080/13651501.2017.1417442
  9. Arshad, M. T., Maqsood, S., Ikram, A., & Abdullahi, M. A. (2025). Functional, nutraceutical, and health-endorsing perspectives of Ashwagandha. EFood, 6(3), e70061. https://doi.org/10.1002/EFD2.70061
  10. Arumugam, V., Vijayakumar, V., Balakrishnan, A., Bhandari, R. B., Boopalan, D., Ponnurangam, R., Sankaralingam, V., & Kuppusamy, M. (2024). Effects of Ashwagandha (Withania Somnifera) on stress and anxiety: a systematic review and meta-analysis. EXPLORE, 20(6), 103062. https://doi.org/10.1016/J.EXPLORE.2024.103062
  11. Atteeq, M. (2022). Evaluating anticancer properties of Withaferin A—a potent phytochemical. Frontiers in Pharmacology, 13, 975320. https://doi.org/10.3389/FPHAR.2022.975320
  12. Awang, D., La, Z., Baima, K., Xie, H., Wang, L., Liu, X., Wang, Y., Shi, Y., Zhao, Y., & Gongga, L. (2025). Salidroside from Rhodiola Rosea L. attenuates high-altitude hypoxic myocardial injury via modulating oxidative stress and Akt/Gsk-3β signaling. https://doi.org/10.2139/SSRN.5384513
  13. Bai, R., Zhao, Z., Han, X., Shang, M., Liu, G., Xu, F., & Cai, S. (2025). Therapeutic potential of ginsenosides in anthracycline-induced cardiotoxicity. Molecules, 30(12), 2527. https://doi.org/10.3390/MOLECULES30122527
  14. Basarrate, S., Monzel, A. S., Smith, J. L. M., Marsland, A. L., Trumpff, C., & Picard, M. (2024). Glucocorticoid and adrenergic receptor distribution across human organs and tissues: a map for stress transduction. Psychosomatic Medicine, 86(2), 89–98. https://doi.org/10.1097/PSY.0000000000001275
  15. Bashir, A., Nabi, M., Tabassum, N., Afzal, S., & Ayoub, M. (2023). An updated review on phytochemistry and molecular targets of Withania somnifera (L.) Dunal (Ashwagandha). Frontiers in Pharmacology, 14, 1049334. https://doi.org/10.3389/FPHAR.2023.1049334
  16. Basudkar, V., Gujrati, G., Ajgaonkar, S., Gandhi, M., Mehta, D., & Nair, S. (2024). Emerging vistas for the nutraceutical Withania somnifera in inflammaging. Pharmaceuticals, 17(5), 597. https://doi.org/10.3390/PH17050597
  17. Bernatoniene, J., Jakstas, V., & Kopustinskiene, D. M. (2023). Phenolic compounds of Rhodiola rosea L. as the potential alternative therapy in the treatment of chronic diseases. International Journal of Molecular Sciences, 24(15), 12293. https://doi.org/10.3390/IJMS241512293
  18. Bian, S., Liu, M., Yang, S., Lu, S., Wang, S., Bai, X., Zhao, D., & Wang, J. (2021). 20(S)-Ginsenoside Rh2-induced apoptosis and protective autophagy in cervical cancer cells by inhibiting AMPK/mTOR pathway. Bioscience, Biotechnology, and Biochemistry, 86(1), 92–103. https://doi.org/10.1093/BBB/ZBAB189
  19. Bian, X. B., Yu, P. C., Yang, X. H., Han, L., Wang, Q. Y., Zhang, L., Zhang, L. X., & Sun, X. (2023). The effect of ginsenosides on liver injury in preclinical studies: a systematic review and meta-analysis. Frontiers in Pharmacology, 14, 1184774. https://doi.org/10.3389/FPHAR.2023.1184774
  20. Bilia, A. R., & Bergonzi, M. C. (2019). The G115 standardized ginseng extract: an example for safety, efficacy, and quality of an herbal medicine. Journal of Ginseng Research, 44(2), 179-193. https://doi.org/10.1016/J.JGR.2019.06.003
  21. Cai, J., Huang, K., Han, S., Chen, R., Li, Z., Chen, Y., Chen, B., Li, S., Xinhua, L., & Yao, H. (2022). A comprehensive system review of pharmacological effects and relative mechanisms of Ginsenoside Re: recent advances and future perspectives. Phytomedicine, 102, 154119. https://doi.org/10.1016/J.PHYMED.2022.154119
  22. Che, W., Wojitas, L., Shan, C., & Lopchuk, J. M. (2024). Divergent synthesis of complex withanolides enabled by a scalable route and late-stage functionalization. Science Advances, 10(26), eadp9375. https://doi.org/10.1126/SCIADV.ADP9375
  23. Cheah, K. L., Norhayati, M. N., Yaacob, L. H., & Rahman, R. A. (2021). Effect of Ashwagandha (Withania somnifera) extract on sleep: a systematic review and meta-analysis. PLOS ONE, 16(9), e0257843. https://doi.org/10.1371/JOURNAL.PONE.0257843
  24. Chen, P., Liu, M., Xiao, H., Luo, T., Ling, H., Chen, X., Li, Z., Xu, S., Li, Z., & Deng, J. (2025). Ginsenoside Re ameliorates cardiac hypertrophy by regulating CaSR-mediated signaling pathway. International Journal of Drug Discovery and Pharmacology, 4(1), 2504000183. https://doi.org/10.53941/IJDDP.2025.100006
  25. Chen, Q., Yang, C., Wang, D., Luo, S., & Ma, S. (2025). Rhodiola rosea stimulates brain microcirculation in rats with hypoxic brain injury at high altitude. Pakistan Journal of Zoology, 57(4), 1883–1888. https://doi.org/10.17582/JOURNAL.PJZ/20240206130209
  26. Chen, W., Balan, P., & Popovich, D. G. (2020). Comparison of ginsenoside components of various tissues of New Zealand forest-grown Asian ginseng (Panax Ginseng) and American ginseng (Panax Quinquefolium L.). Biomolecules, 10(3), 372. https://doi.org/10.3390/BIOM10030372
  27. Chen, Y., Tang, M., Yuan, S., Fu, S., Li, Y., Li, Y., Wang, Q., Cao, Y., Liu, L., & Zhang, Q. (2022). Rhodiola rosea: a therapeutic candidate on cardiovascular diseases. Oxidative Medicine and Cellular Longevity, 2022(1), 1348795. https://doi.org/10.1155/2022/1348795
  28. Chopra, P., Chhillar, H., Kim, Y. J., Jo, I. H., Kim, S. T., & Gupta, R. (2023). Phytochemistry of ginsenosides: recent advancements and emerging roles. Critical Reviews in Food Science and Nutrition, 63(5), 613–640. https://doi.org/10.1080/10408398.2021.1952159
  29. Chu, L. L., Montecillo, J. A. V., & Bae, H. (2020). Recent advances in the metabolic engineering of yeasts for ginsenoside biosynthesis. Frontiers in Bioengineering and Biotechnology, 8, 515823. https://doi.org/10.3389/FBIOE.2020.00139
  30. Concerto, C., Infortuna, C., Muscatello, M. R. A., Bruno, A., Zoccali, R., Chusid, E., Aguglia, E., & Battaglia, F. (2018). Exploring the effect of adaptogenic Rhodiola Rosea extract on neuroplasticity in humans. Complementary Therapies in Medicine, 41, 141–146. https://doi.org/10.1016/j.ctim.2018.09.013
  31. Cong, L., Ma, J., Zhang, Y., Zhou, Y., Cong, X., & Hao, M. (2023). Effect of anti-skin disorders of ginsenosides- A systematic review. Journal of Ginseng Research, 47(5), 605–614. https://doi.org/10.1016/J.JGR.2023.04.005
  32. Cui, J., Shan, R., Cao, Y., Zhou, Y., Liu, C., & Fan, Y. (2021). Protective effects of ginsenoside Rg2 against memory impairment and neuronal death induced by Aβ25-35 in rats. Journal of Ethnopharmacology, 266, 113466. https://doi.org/10.1016/J.JEP.2020.113466
  33. Dai, Y. L., Qiao, M. D., Yu, P., Zheng, F., Yue, H., & Liu, S. Y. (2020). Comparing eight types of ginsenosides in ginseng of different plant ages and regions using RRLC-Q-TOF MS/MS. Journal of Ginseng Research, 44(2), 205–214. https://doi.org/10.1016/J.JGR.2017.11.001
  34. Dar, N. J., Bhat, J. A., Satti, N. K., Sharma, P. R., Hamid, A., & Ahmad, M. (2017). Withanone, an active constituent from Withania somnifera, affords protection against NMDA-induced excitotoxicity in neuron-like cells. Molecular Neurobiology, 54(7), 5061–5073. https://doi.org/10.1007/S12035-016-0044-7
  35. De Oliveira, B., de Oliveira, A. R., Miola, V. F. B., Gissoni, L. M., Spilla, C. S. G., & Barbalho, S. M. (2022). Panax ginseng and aging related disorders: a systematic review. Experimental Gerontology, 161, 111731. https://doi.org/10.1016/J.EXGER.2022.111731
  36. Della Porta, M., Maier, J. A., & Cazzola, R. (2023). Effects of Withania somnifera on cortisol levels in stressed human subjects: a systematic review. Nutrients, 15(24), 5015. https://doi.org/10.3390/NU15245015
  37. Deshpande, A., Irani, N., Balkrishnan, R., & Benny, I. R. (2020). A randomized, double blind, placebo controlled study to evaluate the effects of ashwagandha (Withania somnifera) extract on sleep quality in healthy adults. Sleep Medicine, 72, 28–36. https://doi.org/10.1016/J.SLEEP.2020.03.012
  38. Dimpfel, W., Schombert, L., & Panossian, A. G. (2018). Assessing the quality and potential efficacy of commercial extracts of Rhodiola rosea L. by analyzing the salidroside and rosavin content and the electrophysiological activity in hippocampal long-term potentiation, a synaptic model of memory. Frontiers in Pharmacology, 9, 425. https://doi.org/10.3389/FPHAR.2018.00425
  39. Dinel, A. L., Guinobert, I., Lucas, C., Blondeau, C., Bardot, V., Ripoche, I., Berthomier, L., Pallet, V., Layé, S., & Joffre, C. (2019). Reduction of acute mild stress corticosterone response and changes in stress-responsive gene expression in male Balb/c mice after repeated administration of a Rhodiola rosea L. root extract. Food Science & Nutrition, 7(11), 3827–3841. https://doi.org/10.1002/FSN3.1249
  40. Dipankar, S. P., Dani, M. M., Anirudhan, R., Tripathi, D., Mishra, C., & Devi, S. H. (2025). Pharmacological insights into Ashwagandha (Withania somnifera): a review of its immunomodulatory and neuroprotective properties. Cureus, 17(8), e89856. https://doi.org/10.7759/CUREUS.89856
  41. Dongre, S., Langade, D., & Bhattacharyya, S. (2015). Efficacy and safety of Ashwagandha (Withania somnifera) root extract in improving sexual function in women: a pilot study. BioMed Research International, 2015(1), 284154. https://doi.org/10.1155/2015/284154
  42. Dormal, V., Jonniaux, L., Buchet, M., Simar, L., Copine, S., & Deldicque, L. (2025). Effect of hydroponically grown red panax ginseng on perceived stress level, emotional processing, and cognitive functions in moderately stressed adults: a randomized, double-blind, placebo-controlled study. Nutrients, 17(6), 955. https://doi.org/10.3390/NU17060955
  43. Dutta, R., Khalil, R., Green, R., Mohapatra, S. S., & Mohapatra, S. (2019). Withania Somnifera (Ashwagandha) and Withaferin A: potential in integrative oncology. International Journal of Molecular Sciences, 20(21), 5310. https://doi.org/10.3390/IJMS20215310
  44. Edwards, D., Heufelder, A., & Zimmermann, A. (2012). Therapeutic effects and safety of Rhodiola rosea extract WS® 1375 in subjects with life-stress symptoms--results of an open-label study. Phytotherapy Research, 26(8), 1220–1225. https://doi.org/10.1002/PTR.3712
  45. Er, B., Ozmen, B., Sahin, E., Orhan, C., Sahin, N., Morde, A. A., Padigaru, M., & Sahin, K. (2025). A novel Ashwagandha (Withania somnifera) formulation mitigates sleep deprivation-induced cognitive impairment and oxidative stress in a rat model. Biomolecules, 15(5), 710. https://doi.org/10.3390/BIOM15050710
  46. Esmaealzadeh, N., Iranpanah, A., Sarris, J., & Rahimi, R. (2022). A literature review of the studies concerning selected plant-derived adaptogens and their general function in body with a focus on animal studies. Phytomedicine, 105, 154354. https://doi.org/10.1016/j.phymed.2022.154354
  47. Fan, S., Zhang, Z., Su, H., Xu, P., Qi, H., Zhao, D., & Li, X. (2020). Panax ginseng clinical trials: current status and future perspectives. Biomedicine & Pharmacotherapy, 132, 110832. https://doi.org/10.1016/J.BIOPHA.2020.110832
  48. Fan, W., Fan, L., Wang, Z., Mei, Y., Liu, L., Li, L., Yang, L., & Wang, Z. (2024). Rare ginsenosides: a unique perspective of ginseng research. Journal of Advanced Research, 66, 303-328. https://doi.org/10.1016/J.JARE.2024.01.003
  49. Fang, F., Chen, X., Huang, T., Lue, L. F., Luddy, J. S., & Yan, S. S. (2011). Multi-faced neuroprotective effects of Ginsenoside Rg1 in an Alzheimer mouse model. Biochimica et Biophysica Acta, 1822(2), 286. https://doi.org/10.1016/J.BBADIS.2011.10.004
  50. Fang, X., Zhou, X., Wang, Y., Zhang, W., Wu, H., Xu, L., Sun, M., & Xiao, H. (2024). Determining the genetic basis of ginsenosides variation during ginseng domestication by evolutionary transcriptomics. Industrial Crops and Products, 212, 118369. https://doi.org/10.1016/J.INDCROP.2024.118369
  51. Fanibunda, S. E., Kukkemane, K., Ghai, U., Kolthur-Seetharam, U., Hingorani, L., Vaidya, A. D. B., & Vaidya, V. A. (2025). Withania somnifera regulates mitochondrial biogenesis and energetics in rat cortical neurons: role of BDNF and SIRT1. Molecular Neurobiology, 62(8), 10277–10295. https://doi.org/10.1007/S12035-025-04920-7
  52. Feng, H., Xue, M., Deng, H., Cheng, S., Hu, Y., & Zhou, C. (2022). Ginsenoside and its therapeutic potential for cognitive impairment. Biomolecules, 12(9), 1310. https://doi.org/10.3390/BIOM12091310
  53. Ferreira, J. F., Ferreira, R. M., Maia, F., Fernandes, L. G., Leão, C., & Pimenta, N. (2025). Biopsychological effects of Ashwagandha (Withania somnifera) in athletes and healthy individuals: a systematic review. Muscles, 4(3), 24. https://doi.org/10.3390/MUSCLES4030024
  54. Fu, H., Zhang, Y., An, Q., Wang, D., You, S., Zhao, D., Zhang, J., Wang, C., & Li, M. (2022). Anti-photoaging effect of Rhodiola rosea fermented by Lactobacillus plantarum on UVA-damaged fibroblasts. Nutrients, 14(11), 2324. https://doi.org/10.3390/NU14112324
  55. Gao, L., Wu, C., Liao, Y., Zhang, S., & Zhao, J. (2021). Herba Rhodiolae alleviates depression via the BDNF/TrkB-GSK-3β signaling pathway. Annals of Translational Medicine, 9(24), 1758–1758. https://doi.org/10.21037/ATM-21-5849
  56. Gaurav, H., Yadav, D., Maurya, A., Yadav, H., Yadav, R., Shukla, A. C., Sharma, M., Gupta, V. K., & Palazon, J. (2023). Biodiversity, biochemical profiling, and pharmaco-commercial applications of Withania somnifera: a review. Molecules, 28(3), 1208. https://doi.org/10.3390/MOLECULES28031208
  57. Gębalski, J., Małkowska, M., Graczyk, F., Słomka, A., Piskorska, E., Gawenda-Kempczyńska, D., Kondrzycka-Dąda, A., Bogucka-Kocka, A., Strzemski, M., Sowa, I., Wójciak, M., Grzyb, S., Krolik, K., Ptaszyńska, A. A., & Załuski, D. (2023). Phenolic compounds and antioxidant and anti-enzymatic activities of selected adaptogenic plants from South America, Asia, and Africa. Molecules, 28(16), 6004. https://doi.org/10.3390/MOLECULES28166004
  58. Geng, B., Zhao, M., Wang, J., Zhong, T., Kang, C., Wang, Z., Ma, X., & Xia, T. (2024). Ginsenoside Rh2 promotes cell apoptosis in T-cell acute lymphocytic leukaemia by MAPK and PI3K/AKT signalling pathways. Natural Product Research. https://doi.org/10.1080/14786419.2024.2440537
  59. Gerontakos, S. E., Wardle, J., & Casteleijn, D. (2020). A critical review to identify the domains used to measure the effect and outcome of adaptogenic herbal medicines. Advances in Integrative Medicine, 6(1), 133-134. https://doi.org/10.1016/j.aimed.2019.03.389
  60. Girme, A., Saste, G., Pawar, S., Balasubramaniam, A. K., Musande, K., Darji, B., Satti, N. K., Verma, M. K., Anand, R., Singh, R., Vishwakarma, R. A., & Hingorani, L. (2020). Investigating 11 withanosides and withanolides by UHPLC–PDA and mass fragmentation studies from Ashwagandha (Withania somnifera). ACS Omega, 5(43), 27933–27943. https://doi.org/10.1021/ACSOMEGA.0C03266
  61. Gokdemir, G. S., Seker, U., Baksi, N., Baylan, M., Demirtaş, B., & Gokdemir, M. T. (2026). Antidepressant-like effects of Ashwagandha (Withania Somnifera) on chronic unpredictable mild stress-induced depression in adolescent rats. Psychopharmacology, 243, 117–132. https://doi.org/10.1007/S00213-025-06844-5
  62. Gómez, A., Fernandez-Lazaro, D., Adams, D. P., Monserdà-Vilaró, A., & Fernandez-Lazaro, C. I. (2023). Effects of Withania somnifera (Ashwagandha) on hematological and biochemical markers, hormonal behavior, and oxidant response in healthy adults: a systematic review. Current Nutrition Reports, 12(3), 465–477. https://doi.org/10.1007/S13668-023-00481-0
  63. Gong, L., Yin, J., Zhang, Y., Huang, R., Lou, Y., Jiang, H., Sun, L., Jia, J., & Zeng, X. (2022). Neuroprotective mechanisms of ginsenoside Rb1 in central nervous system diseases. Frontiers in Pharmacology, 13, 914352. https://doi.org/10.3389/FPHAR.2022.914352
  64. Gopukumar, K., Thanawala, S., Somepalli, V., Rao, T. S. S., Thamatam, V. B., & Chauhan, S. (2021). Efficacy and safety of Ashwagandha root extract on cognitive functions in healthy, stressed adults: a randomized, double-blind, placebo-controlled study. Evidence-Based Complementary and Alternative Medicine, 2021(1), 8254344. https://doi.org/10.1155/2021/8254344
  65. Guo, S., & Rezaei, M. J. (2024). The benefits of ashwagandha (Withania somnifera) supplements on brain function and sports performance. Sports and Exercise Nutrition, 11. https://doi.org/10.3389/FNUT.2024.1439294
  66. Gupta, M., & Kaur, G. (2016). Aqueous extract from the Withania somnifera leaves as a potential anti-neuroinflammatory agent: a mechanistic study. Journal of Neuroinflammation, 13(193). https://doi.org/10.1186/S12974-016-0650-3
  67. Gurav, S., Wanjari, M., Bhole, R., Raut, N., Prasad, S., Saoji, S., Chikhale, R., Khanal, P., Pant, A., Ayyanar, M., & Gurav, N. (2023). Ethnological validation of Ashwagandha (Withania somnifera L. Dunal) ghrita as ‘Vajikarana Rasayana’: In-silico, in-vitro and in-vivo approach. Journal of Ethnopharmacology, 304, 116064. https://doi.org/10.1016/J.JEP.2022.116064
  68. Haber, M., Czachor, A., Kula, P., Juśkiewicz, A., Grelewicz, O., Kucy, N., Servaas, E., Kotula, A., & Siemiątkowski, R. (2024). Ashwagandha as an adaptogen: its influence on sleep patterns, stress response, and anxiety in modern life. Journal of Education, Health and Sport, 68, 55327. https://doi.org/10.12775/JEHS.2024.68.55327
  69. Han, D., Zhao, Z., Mao, T., Gao, M., Yang, X., & Gao, Y. (2024). Ginsenoside Rg1: a neuroprotective natural dammarane‐type triterpenoid saponin with anti‐depressive properties. CNS Neuroscience & Therapeutics, 30(12), e70150. https://doi.org/10.1111/CNS.70150
  70. Han, J. Y., Kim, H. J., Kwon, Y. S., & Choi, Y. E. (2011). The Cyt P450 enzyme CYP716A47 catalyzes the formation of protopanaxadiol from dammarenediol-II during ginsenoside biosynthesis in Panax ginseng. Plant and Cell Physiology, 52(12), 2062–2073. https://doi.org/10.1093/PCP/PCR150
  71. Hasanyn, R. F., Batawi, A. H., Al-Thepyani, M. A., Tash, R., Almuhammadi, A., Alsabban, A. H., & Alghamdi, B. S. (2025). Ashwagandha root extract mitigates fibromyalgia-like symptoms via neurochemical and histological modulation in mice. Cells, 14(18), 1478. https://doi.org/10.3390/CELLS14181478
  72. Hernández-Santana, A., Pérez-López, V., Zubeldia, J. M., & Jiménez-Del-Rio, M. (2014). A Rhodiola rosea root extract protects skeletal muscle cells against chemically induced oxidative stress by modulating heat shock protein 70 (HSP70) expression. Phytotherapy Research, 28(4), 623–628. https://doi.org/10.1002/PTR.5046
  73. Hou, J., Cui, C., Kim, S., Sung, C., & Choi, C. (2018). Ginsenoside F1 suppresses astrocytic senescence-associated secretory phenotype. Chemico-Biological Interactions, 283, 75–83.
  74. https://doi.org/10.1016/J.CBI.2018.02.002
  75. Hou, J., Yun, Y., Jeon, B., Baek, J., & Kim, S. (2023). Ginsenoside F1-mediated telomere preservation delays cellular senescence. International Journal of Molecular Sciences, 24(18), 14241. https://doi.org/10.3390/IJMS241814241
  76. Hou, M., Wang, R., Zhao, S., & Wang, Z. (2021). Ginsenosides in Panax genus and their biosynthesis. Acta Pharmaceutica Sinica B, 11(7), 1813–1834. https://doi.org/10.1016/J.APSB.2020.12.017
  77. Hou, W., Wang, Y., Zheng, P., & Cui, R. (2020). Effects of ginseng on neurological disorders. Frontiers in Cellular Neuroscience, 14, 510085. https://doi.org/10.3389/FNCEL.2020.00055
  78. Hu, Y., Cho, J. Y., & Kim, M. Y. (2025). Pharmacokinetics and pharmacological activities of protopanaxatriol. Journal of Ginseng Research, 49(6), 613-621. https://doi.org/10.1016/J.JGR.2025.07.004
  79. Huang, C., Li, P., Yang, X., Niu, T., Zhao, S., Yang, L., Wang, R., & Wang, Z. (2023). Integrated transcriptome and proteome analyses reveal candidate genes for ginsenoside biosynthesis in Panax japonicus C. A. Meyer. Frontiers in Plant Science, 13, 1106145. https://doi.org/10.3389/FPLS.2022.1106145
  80. Huang, X., Daneshi, M., Falahatzadeh, M., & Rounagh, M. (2025). The effect of ginseng supplementation and health outcomes: a GRADE-assessed systematic review and meta-analysis of randomized controlled trials. Journal of Functional Foods, 129, 106879. https://doi.org/10.1016/J.JFF.2025.106879
  81. Hung, S. K., Perry, R., & Ernst, E. (2011). The effectiveness and efficacy of Rhodiola rosea L.: a systematic review of randomized clinical trials. Phytomedicine, 18(4), 235–244. https://doi.org/10.1016/j.phymed.2010.08.014
  82. Hyun, S. H., Bhilare, K. D., In, G., Park, C. K., & Kim, J. H. (2021). Effects of Panax ginseng and ginsenosides on oxidative stress and cardiovascular diseases: pharmacological and therapeutic roles. Journal of Ginseng Research, 46(1), 33-38. https://doi.org/10.1016/J.JGR.2021.07.007
  83. Irfan, M., Kwak, Y. S., Han, C. K., Hyun, S. H., & Rhee, M. H. (2020). Adaptogenic effects of Panax ginseng on modulation of cardiovascular functions. Journal of Ginseng Research, 44(4), 538–543. https://doi.org/10.1016/J.JGR.2020.03.001
  84. Jang, W. Y., Hwang, J. Y., & Cho, J. Y. (2023). Ginsenosides from Panax ginseng as key modulators of NF-κB signaling are powerful anti-inflammatory and anticancer agents. International Journal of Molecular Sciences, 24(7), 6119. https://doi.org/10.3390/IJMS24076119
  85. Jayawardena, R., Weerasinghe, K., & Sooriyaarachchi, P. (2025). The effect of Ashwagandha (Withania somnifera) on sports performance: a systematic review and meta-analysis. Spor Hekimliği Dergisi, 60(2), 064–073. https://doi.org/10.47447/TJSM.0862
  86. Jeong, J. S., Kim, J. W., Kim, J. H., Kim, C. Y., Chung, E. H., Boo, S. Y., Giorgi, M., Ko, J. W., & Kim, T. W. (2025). Pharmacokinetic variability of 20(S)-protopanaxadiol-type ginsenosides Rb1, rd, and compound K from Korean red ginseng in experimental rodents. Scientific Reports, 15(1), 28072. https://doi.org/10.1038/S41598-025-13873-9
  87. Jo, H., Jang, D., Park, S. K., Lee, M. G., Cha, B., Park, C., Shin, Y. S., Park, H., Baek, J., Heo, H., Brito, S., Hwan, H. G., Chae, S., Yan, S., Lee, C., Min, C. K., & Bin, B. H. (2021). Ginsenoside 20(S)-protopanaxadiol induces cell death in human endometrial cancer cells via apoptosis. Journal of Ginseng Research, 45(1), 126–133. https://doi.org/10.1016/j.jgr.2020.02.002
  88. Jówko, E., Sadowski, J., Długołęcka, B., Gierczuk, D., Opaszowski, B., & Cieśliński, I. (2018). Effects of Rhodiola rosea supplementation on mental performance, physical capacity, and oxidative stress biomarkers in healthy men. Journal of Sport and Health Science, 7(4), 473–480. https://doi.org/10.1016/J.JSHS.2016.05.005
  89. Jurcău, R., Lambinet, M., Jurcău, I., & Rusu, L. D. (2019). A PubMed evaluation of the Rhodiola rosea adaptogen. Health, Sports & Rehabilitation Medicine, 20(4), 174–178. https://doi.org/10.26659/PM3.2019.20.4.174
  90. Jurcău, R. N., Jurcău, I. M., Lambinet, M., Colceriu, N. A., Trif, F. G., & Kwak, D. H. (2025). Modulatory role of Rhodiola Rosea in anxiety and stress: a PubMed approach. BULETIN ŞTIINŢIFIC SERIA A Fascicula Pedagogie-Psihologie-Metodică, 25, 211–218. https://doi.org/10.37193/BS-PPM.25.19
  91. Kang, O. J., & Kim, J. S. (2016). Comparison of ginsenoside contents in different parts of Korean ginseng (Panax ginseng C.A. Meyer). Preventive Nutrition and Food Science, 21(4), 389–392. https://doi.org/10.3746/PNF.2016.21.4.389
  92. Kang, S., & Min, H. (2012). Ginseng, the “Immunity Boost”: the effects of Panax ginseng on immune system. Journal of Ginseng Research, 36(4), 354-368. https://doi.org/10.5142/JGR.2012.36.4.354
  93. Kanyaiya, M., Digambar, S. P., Arora, S., Kapila, S., & Singh, R. R. B. (2014). In vivo, effect of herb (Withania somnifera) on immunomodulatory and antioxidative potential of milk in mice. Food and Agricultural Immunology, 25(3), 443–452. https://doi.org/10.1080/09540105.2013.837032
  94. Karimi, M., Barjasteh, A. H., Shariatzadeh, M., Taha, S. R., Fazlollahpour-naghibi, A., Rezaei, P., Aghaei, M., Ghanbari, M., & Pourhanifeh, M. H. (2025). Ginsenosides and gastrointestinal cancers: a novel therapeutic strategy in cancer therapy. Pathology - Research and Practice, 272, 156078. https://doi.org/10.1016/J.PRP.2025.156078
  95. Kasprzyk, P. G., Tremaine, L., Fahmi, O. A., & Weng, J. K. (2023). In Vitro evaluation of the potential for drug interactions by salidroside. Nutrients, 15(17), 3723. https://doi.org/10.3390/NU15173723
  96. Kaur, J., Seshadri, S., Golla, K. H., & Sampara, P. (2022). Efficacy and safety of standardized Ashwagandha (Withania somnifera) root extract on reducing stress and anxiety in domestic dogs: a randomized controlled trial. Journal of Veterinary Behavior, 51, 8–15. https://doi.org/10.1016/J.JVEB.2022.03.002
  97. Khalil, H. M. A., Eliwa, H. A., El-Shiekh, R. A., Al-Mokaddem, A. K., Hassan, M., Tawfek, A. M., & El-Maadawy, W. H. (2021). Ashwagandha (Withania somnifera) root extract attenuates hepatic and cognitive deficits in thioacetamide-induced rat model of hepatic encephalopathy via induction of Nrf2/HO-1 and mitigation of NF-κB/MAPK signaling pathways. Journal of Ethnopharmacology, 277, 114141. https://doi.org/10.1016/J.JEP.2021.114141
  98. Khan, M. A., Ahmed, R. S., Chandra, N., Arora, V. K., & Ali, A. (2019). In vivo, extract from Withania somnifera root ameliorates arthritis via regulation of key immune mediators of inflammation in experimental model of arthritis. Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 18(1), 55. https://doi.org/10.2174/1871523017666181116092934
  99. Kim, D., Kim, M., Raña, G. S., & Han, J. (2018). Seasonal variation and possible biosynthetic pathway of ginsenosides in Korean ginseng Panax ginseng Meyer. Molecules, 23(7), 1824. https://doi.org/10.3390/MOLECULES23071824
  100. Kim, H., Choi, H. S., Han, K., Sim, W., Suh, H. J., & Ahn, Y. (2025). Ashwagandha (Withania somnifera (L.) dunal) root extract containing withanolide a alleviates depression-like behavior in mice by enhancing the brain-derived neurotrophic factor pathway under unexpected chronic mild stress. Journal of Ethnopharmacology, 340, 119224. https://doi.org/10.1016/J.JEP.2024.119224
  101. Kim, H. W., Kim, D. H., Ryu, B., Chung, Y. J., Lee, K., Kim, Y. C., Lee, J. W., Kim, D. H., Jang, W., Cho, W., Shim, H., Sung, S. H., Yang, T. J., & Kang, K. B. (2024). Mass spectrometry-based ginsenoside profiling: recent applications, limitations, and perspectives. Journal of Ginseng Research, 48(2), 149-162. https://doi.org/10.1016/J.JGR.2024.01.004
  102. Kim, J. H., Yi, Y. S., Kim, M. Y., & Cho, J. Y. (2017). Role of ginsenosides, the main active components of Panax ginseng, in inflammatory responses and diseases. Journal of Ginseng Research, 41(4), 435–443. https://doi.org/10.1016/J.JGR.2016.08.004
  103. Kim, J. K., Choi, M. S., Park, H. S., Kee, K. H., Kim, D. H., & Yoo, H. H. (2023). Pharmacokinetic profiling of ginsenosides, Rb1, Rd, and Rg3, in mice with antibiotic-induced gut microbiota alterations: implications for variability in the therapeutic efficacy of red ginseng extracts. Foods, 12(23), 43-42. https://doi.org/10.3390/FOODS12234342
  104. Kim, Y. J., Zhang, D., & Yang, D. C. (2015). Biosynthesis and biotechnological production of ginsenosides. Biotechnology Advances, 33(6), 717–735. https://doi.org/10.1016/J.BIOTECHADV.2015.03.001
  105. Kim, Y. S., Woo, J. Y., Han, C. K., & Chang, I. M. (2015). Safety analysis of Panax Ginseng in randomized clinical trials: a systematic review. Medicines, 2(2), 106-126. https://doi.org/10.3390/MEDICINES2020106
  106. Krishnaraju, A. V., Somepalli, V., Thanawala, S., & Shah, R. (2023). Efficacy and anti-inflammatory activity of ashwagandha sustained-release formulation on depression and anxiety induced by chronic unpredictable stress: in vivo and in vitro studies. Journal of Experimental Pharmacology, 15, 291. https://doi.org/10.2147/JEP.S407906
  107. Kumar, P., Sharma, R., & Garg, N. (2022). Withania somnifera - a magic plant targeting multiple pathways in cancer related inflammation. Phytomedicine, 101, 154137. https://doi.org/10.1016/j.phymed.2022.154137
  108. Kumar, S., Mathew, S. O., Aharwal, R. P., Tulli, H. S., Mohan, C. D., Sethi, G., Ahn, K. S., Webber, K., Sandhu, S. S., & Bishayee, A. (2023). Withaferin A: a pleiotropic anticancer agent from the Indian medicinal plant Withania somnifera (L.) Dunal. Pharmaceuticals, 16(2), 160. https://doi.org/10.3390/PH16020160
  109. Langade, D., Kanchi, S., Salve, J., Debnath, K., & Ambegaokar, D. (2019). Efficacy and safety of Ashwagandha (Withania somnifera) root extract in insomnia and anxiety: a double-blind, randomized, placebo-controlled study. Cureus, 11(9). https://doi.org/10.7759/CUREUS.5797
  110. Le, M. H., Ahn, Y. H., Lee, H. J., & Kim, Y. J. (2024). Stem-and-leaf of new hydroponically-cultured ginseng cultivar
  111. K-1: a sustainable and innovative resource of ginsenosides for anti-inflammatory agents. Journal of Ginseng Research, 48(6), 616–626. https://doi.org/10.1016/J.JGR.2024.07.001
  112. Lee, D. H., Ahn, J., Jang, Y. J., Seo, H. D., Ha, T. Y., Kim, M. J., Huh, Y. H., & Jung, C. H. (2020). Withania somnifera extract enhances energy expenditure via improving mitochondrial function in adipose tissue and skeletal muscle. Nutrients, 12(2), 431. https://doi.org/10.3390/NU12020431
  113. Lee, K., Lee, D., Kim, J. Y., Shim, J. J., Bae, J. W., & Lee, J. H. (2025). Attenuation effect of Withania somnifera extract on restraint stress-induced anxiety-like behavior and hippocampal alterations in mice. International Journal of Molecular Sciences, 26(15), 7317. https://doi.org/10.3390/IJMS26157317
  114. Lee, N. H., Yoo, S. R., Kim, H. G., Cho, J. H., & Son, C. G. (2012). Safety and tolerability of panax ginseng root extract: a randomized, placebo-controlled, clinical trial in healthy Korean volunteers. Journal of Alternative and Complementary Medicine, 18(11), 1061. https://doi.org/10.1089/ACM.2011.0591
  115. Lee, R., Kim, J. H., Kim, W. W., Hwang, S. H., Choi, S. H., Kim, J. H., Cho, I. H., Kim, M., & Nah, S. Y. (2024). Emerging evidence that ginseng components improve cognition in subjective memory impairment, mild cognitive impairment, and early Alzheimer’s disease dementia. Journal of Ginseng Research, 48(3), 245–252. https://doi.org/10.1016/J.JGR.2024.02.002
  116. Lee, S., & Rhee, D. K. (2017). Effects of ginseng on stress-related depression, anxiety, and the hypothalamic–pituitary–adrenal axis. Journal of Ginseng Research, 41(4), 589–594. https://doi.org/10.1016/J.JGR.2017.01.010
  117. Lee, Y. M., Yoon, H., Park, H. M., Song, B. C., & Yeum, K. J. (2017). Implications of red Panax ginseng in oxidative stress associated chronic diseases. Journal of Ginseng Research, 41(2), 113–119. https://doi.org/10.1016/J.JGR.2016.03.003
  118. Leonard, M., Dickerson, B., Estes, L., Gonzalez, D. E., Jenkins, V., Johnson, S., Xing, D., Yoo, C., Ko, J., Purpura, M., Jäger, R., Faries, M., Kephart, W., Sowinski, R., Rasmussen, C. J., & Kreider, R. B. (2024). Acute and repeated ashwagandha supplementation improves markers of cognitive function and mood. Nutrients, 16(12), 1813. https://doi.org/10.3390/NU16121813
  119. Lerose, V., Ponticelli, M., Benedetto, N., Carlucci, V., Lela, L., Tzvetkov, N. T., & Milella, L. (2024). Withania somnifera (L.) Dunal, a potential source of phytochemicals for treating neurodegenerative diseases: a systematic review. Plants, 13(6), 771. https://doi.org/10.3390/PLANTS13060771
  120. Li, F., Lv, C., Li, Q., Wang, J., Song, D., Liu, P., Zhang, D., & Lu, J. (2017). Chemical and bioactive comparison of flowers of Panax ginseng Meyer, Panax quinquefolius L., and Panax notoginseng Burk. Journal of Ginseng Research, 41(4), 487–495. https://doi.org/10.1016/J.JGR.2016.08.008
  121. Li, J., Huang, Q., Yao, Y., Ji, P., Mingyao, E., Chen, J., Zhang, Z., Qi, H., Liu, J., Chen, Z., Zhao, D., Zhou, L., & Li, X. (2022). Biotransformation, pharmacokinetics, and pharmacological activities of ginsenoside Rd against multiple diseases. Frontiers in Pharmacology, 13, 909363. https://doi.org/10.3389/FPHAR.2022.909363
  122. Li, X., Cheng, X., Liao, B., Xu, J., Han, X., Zhang, J., Lin, Z., & Hu, L. (2021). Spatial protein expression of Panax ginseng by in-depth proteomic analysis for ginsenoside biosynthesis and transportation. Journal of Ginseng Research, 45(1), 58–65. https://doi.org/10.1016/J.JGR.2020.01.009
  123. Li, Y., Pham, V., Bui, M., Song, L., Wu, C., Walia, A., Uchio, E., Smith-Liu, F., & Zi, X. (2017). Rhodiola rosea L.: an herb with anti-stress, anti-aging, and immunostimulating properties for cancer chemoprevention. Current Pharmacology Reports, 3(6), 384. https://doi.org/10.1007/S40495-017-0106-1
  124. Liang, C. J. W., Woerdenbag, H. J., Ekhart, C., Vitalone, A., & van Hunsel, F. P. A. M. (2025). Safety considerations for natural products with adaptogenic and immunomodulating activities. Pharmaceuticals, 18(8), 1208. https://doi.org/10.3390/PH18081208
  125. Liang, J., Tang, X., Wan, S., Guo, J., Zhao, P., & Lu, L. (2023). Structure modification of ginsenoside Rh2 and cytostatic activity on cancer cells. ACS Omega, 8(19), 17245–17253. https://doi.org/10.1021/ACSOMEGA.3C01665
  126. Liao, L. Y., He, Y. F., Li, L., Meng, H., Dong, Y. M., Yi, F., & Xiao, P. G. (2018). A preliminary review of studies on adaptogens: comparison of their bioactivity in TCM with that of ginseng-like herbs used worldwide. Chinese Medicine, 13(57). https://doi.org/10.1186/S13020-018-0214-9
  127. Limanaqi, F., Biagioni, F., Busceti, C. L., Polzella, M., Fabrizi, C., & Fornai, F. (2020). Potential antidepressant effects of Scutellaria baicalensis, Hericium erinaceus and Rhodiola rosea. Antioxidants, 9(3), 234. https://doi.org/10.3390/ANTIOX9030234
  128. Liu, S., Chen, W., Zhao, Y., Zong, Y., Li, J., & He, Z. (2023). Research progress on effects of ginsenoside Rg2 and Rh1 on nervous system and related mechanisms. Molecules, 28(23) 7935. https://doi.org/10.3390/MOLECULES28237935
  129. Liu, W., Zhang, S. X., Ai, B., Pan, H. F., Zhang, D., Jiang, Y., Hu, L. H., Sun, L. L., Chen, Z. S., & Lin, L. Z. (2021). Ginsenoside Rg3 promotes cell growth through activation of mTORC1. Frontiers in Cell and Developmental Biology, 9, 730309. https://doi.org/10.3389/FCELL.2021.730309
  130. Liu, Y., Ju, Y., Wang, Y., Cui, X., Sun, Y., Hu, P., & Chen, Y. (2025). Ginsenoside in the treatment of type 2 diabetes and its complications: a promising traditional Chinese medicine. Frontiers in Pharmacology, 16, 1593780. https://doi.org/10.3389/FPHAR.2025.1593780
  131. Liu, Y., Zong, X., Huang, J., Guan, Y., Li, Y., Du, T., Liu, K., Kang, X., Dou, C., Sun, X., Wu, R., Wen, L., & Zhang, Y. (2019). Ginsenoside Rb1 regulates prefrontal cortical GABAergic transmission in MPTP-treated mice. Aging, 11(14), 5008–5034. https://doi.org/10.18632/AGING.102095
  132. Lopresti, A. L., Smith, S. J., & Drummond, P. D. (2022). Modulation of the hypothalamic-pituitary-adrenal (HPA) axis by plants and phytonutrients: a systematic review of human trials. Nutritional Neuroscience, 25(8), 1704–1730. https://doi.org/10.1080/1028415X.2021.1892253
  133. Lopresti, A. L., Smith, S. J., Malvi, H., & Kodgule, R. (2019). An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: a randomized, double-blind, placebo-controlled study. Medicine, 98(37), e17186. https://doi.org/10.1097/MD.0000000000017186
  134. Lu, Y., Deng, B., Xu, L., Liu, H., Song, Y., & Lin, F. (2022). Effects of Rhodiola Rosea supplementation on exercise and sport: a systematic review. Frontiers in Nutrition, 9. https://doi.org/10.3389/FNUT.2022.856287
  135. Lu, Z., Mao, T., Chen, K., Chai, L., Dai, Y., & Liu, K. (2023). Ginsenoside Rc: a potential intervention agent for metabolic syndrome. Journal of Pharmaceutical Analysis, 13(12), 1375–1387. https://doi.org/10.1016/J.JPHA.2023.08.013
  136. Ma, G. P., Zheng, Q., Xu, M. B., Zhou, X. L., Lu, L., Li, Z. X., & Zheng, G. Q. (2018). Rhodiola rosea L. improves learning and memory function: preclinical evidence and possible mechanisms. Frontiers in Pharmacology, 9, 1415. https://doi.org/10.3389/FPHAR.2018.01415
  137. Maccioni, R., Cottiglia, F., Maccioni, E., Talani, G., Sanna, E., Bassareo, V., Kasture, S. B., & Acquas, E. (2021). The biologically active compound of Withania somnifera (L.) Dunal, docosanyl ferulate, is endowed with potent anxiolytic properties but devoid of typical benzodiazepine-like side effects. Journal of Psychopharmacology (Oxford, England), 35(10), 1277–1284. https://doi.org/10.1177/02698811211008588
  138. Maher, S., Choudhary, M. I., Saleem, F., Rasheed, S., Waheed, I., Halim, S. A., Azeem, M., Abdullah, I. Bin, Froeyen, M., Mirza, M. U., & Ahmad, S. (2020). Isolation of antidiabetic Withanolides from Withania coagulans Dunal and their in vitro and in silico validation. Biology, 9(8), 197. https://doi.org/10.3390/BIOLOGY9080197
  139. Marciniak, A., Nemeczek, S., Walczak, K., Walczak, P., Merkisz, K., Grzybowski, J., Grzywna, N., Jaskuła, K., & Orłowski, W. (2023). Adaptogens-use, history and future. Quality in Sport, 9(1), 19–28. https://doi.org/10.12775/QS.2023.09.01.002
  140. Mariage, P. A., Hovhannisyan, A., & Panossian, A. G. (2020). Efficacy of panax ginseng meyer herbal preparation hrg80 in preventing and mitigating stress-induced failure of cognitive functions in healthy subjects: a pilot, randomized, double-blind, placebo-controlled crossover trial. Pharmaceuticals, 13(4) 57. https://doi.org/10.3390/PH13040057
  141. Masi, F., Chianese, G., Hofstetter, R. K., Cavallaro, A. L., Riva, A., Werz, O., & Taglialatela-Scafati, O. (2023). Phytochemical profile and anti-inflammatory activity of a commercially available Rhodiola rosea root extract. Fitoterapia, 166, 105439. https://doi.org/10.1016/J.FITOTE.2023.105439
  142. McEwen, B. S. (2017). Neurobiological and systemic effects of chronic stress. Chronic Stress (Thousand Oaks, Calif.), 1. https://doi.org/10.1177/2470547017692328
  143. Mehta, J. P., Kagal, U. A., & Biradar, P. R. (2025). Effect of Withania somnifera on expression of selected genes in hippocampus of male wistar rats subjected to chronic unpredictable mild stress. International Journal of Applied and Basic Medical Research, 15(1), 25-31. https://doi.org/10.4103/IJABMR.IJABMR_330_24
  144. Michels, B., Franke, K., Weiglein, A., Sultani, H., Gerber, B., & Wessjohann, L. A. (2020). Rewarding compounds identified from the medicinal plant Rhodiola rosea. The Journal of Experimental Biology, 223(16), jeb223982. https://doi.org/10.1242/JEB.223982
  145. Mikulska, P., Malinowska, M., Ignacyk, M., Szustowski, P., Nowak, J., Pesta, K., Szeląg, M., Szklanny, D., Judasz, E., Kaczmarek, G., Ejiohuo, O. P., Paczkowska-Walendowska, M., Gościniak, A., & Cielecka-Piontek, J. (2023). Ashwagandha (Withania somnifera)—Current research on the health-promoting activities: a narrative review. Pharmaceutics, 15(4), 1057. https://doi.org/10.3390/PHARMACEUTICS15041057
  146. Mishra, D. N., & Kumar, M. (2024). Shoden promotes relief from stress and anxiety: a randomized, double-blind, placebo-controlled study on healthy subjects with high stress levels. Heliyon, 10(17), e36885. https://doi.org/10.1016/J.HELIYON.2024.E36885
  147. Mishra, S. K., Venkatachalapathy, B. A., & Khanli, H. M. (2017). Safety and efficacy of Ashwagandha (Withania somnifera). En G. Brahmachari (ed.), Neuroprotective natural products: clinical aspects and mode of action (pp. 313–319). Wiley. https://doi.org/10.1002/9783527803781
  148. Mohanan, P., Subramaniyam, S., Mathiyalagan, R., & Yang, D. C. (2018). Molecular signaling of ginsenosides Rb1, Rg1, and Rg3 and their mode of actions. Journal of Ginseng Research, 42(2), 123–132. https://doi.org/10.1016/J.JGR.2017.01.008
  149. Mohanan, P., Yang, T. J., & Song, Y. H. (2023). Genes and regulatory mechanisms for ginsenoside biosynthesis. Journal of Plant Biology, 66(1), 87–97. https://doi.org/10.1007/S12374-023-09384-7
  150. Mohsin, M. M., Hanif, M. A., Ayub, M. A., & Dharmadasa, R. M. (2023). Ginseng. En Medicinal Plants of South Asia: Novel Sources for Drug Discovery (pp. 331–340). Elseviere. https://doi.org/10.1016/B978-0-08-102659-5.00025-2
  151. Morshed, M. N., Ahn, J. C., Mathiyalagan, R., Rupa, E. J., Akter, R., Karim, M. R., Jung, D. H., Yang, D. U., Yang, D. C., & Jung, S. K. (2023). Antioxidant activity of panax ginseng to regulate ROS in various chronic diseases. Applied Sciences (Switzerland), 13(5), 2893. https://doi.org/10.3390/APP13052893
  152. Mukherjee, P. K., Banerjee, S., Biswas, S., Das, B., Kar, A., & Katiyar, C. K. (2021). Withania somnifera (L.) Dunal - Modern perspectives of an ancient Rasayana from Ayurveda. Journal of Ethnopharmacology, 264, 113157. https://doi.org/10.1016/j.jep.2020.113157
  153. Murthy, S. V., Fathima, S. N., & Mote, R. (2022). Hydroalcoholic extract of Ashwagandha improves sleep by modulating GABA/Histamine receptors and EEG slow-wave pattern in in vitro - in vivo experimental models. Preventive Nutrition and Food Science, 27(1), 108-120. https://doi.org/10.3746/PNF.2022.27.1.108