Vol. 24 (2014): (NE-2) Ciencias Médicas
Artículos de investigación

IFN-γ, IL-4 and Helicobacter pylori in patients with chronic gastritis and gastric cáncer

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  • Alina Mora González,
  • Víctor Manuel Villegas Román,
  • Josefina Atrisco Morales,
  • Dinorah Nashely Martínez Carrillo,
  • Gloria Fernández Tilapa,
  • Rogelio Hernández Pando,
  • Salomón Reyes Navarrete,
  • Reyes Betancourt Linares,
  • Iván Cruz del Carmen,
  • Berenice Illades Aguiar,
  • Adolfo Román Román
Alina Mora González Universidad Autónoma de Guerrero
Víctor Manuel Villegas Román Universidad Autónoma de Guerrero
Josefina Atrisco Morales Universidad Autónoma de Guerrero
Dinorah Nashely Martínez Carrillo Universidad Autónoma de Guerrero
Gloria Fernández Tilapa Universidad Autónoma de Guerrero
Rogelio Hernández Pando Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
Salomón Reyes Navarrete Instituto Estatal de Cancerología
Reyes Betancourt Linares Unidad Especializada en Gastroenterología Endoscopía,
Iván Cruz del Carmen Hospital General Dr. Raymundo Abarca Alarcón
Berenice Illades Aguiar Universidad Autónoma de Guerrero
Adolfo Román Román Universidad Autónoma de Guerrero

Published 2015-01-12

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How to Cite

IFN-γ, IL-4 and Helicobacter pylori in patients with chronic gastritis and gastric cáncer. (2015). Acta Universitaria, 24, 30-34. https://doi.org/10.15174/au.2014.719

Abstract

The Helicobacter pylori infection is the main factor of risk for gastric cancer, in the immune response induced for the bacterium there is an infiltration of cells which produce high levels of cytokines, which may be involved in gastric carcinogenesis. The objetive of this investigation is to evaluate the relation of the expression of IFN- γ and IL-4 with the H. pylori infection, chronic gastritis and gastric cancer. 100 patients with chronic gastritis and twenty with gastric cancer were included; the expression of INF-g and IL-4 was determined by immunohistochemistry. 57.5% of cases were positive for H. pylori, the highest frequency of IFN- γ expression was found in cases of cancer H. pylori-positive, in the case of IL-4 was more frequent in patients H. pylori-positive with chronic gastritis. The IFN- γ expression frequency was higher than the IL-4 expression. In the majority of the samples H. pylori-positive were expressed the two cytokines.

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References