Vol. 24 (2014): (NE-2) Ciencias Médicas
Artículos de investigación

Methylation of miR-218-1 in squamous intraepithelial lesions of low grade and cervical cancer with HPV 16

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  • Julio César Muñiz Salgado,
  • Rubén Barrientos Noriega,
  • Gabriela Campos Viguri,
  • Hilda Jiménez Wences,
  • Dinorah Nashely Martínez Carrillo,
  • Luz del Carmen Alarcón Romero,
  • Berenice Illades Aguiar,
  • Gloria Fernández Tilapa,
  • José Guadalupe Muñoz Camacho,
  • Marco Antonio Jiménez López,
  • Víctor Hugo Garzón Barrientos,
  • Óscar Peralta Zaragoza
Julio César Muñiz Salgado Universidad Autónoma de Guerrero
Rubén Barrientos Noriega Universidad Autónoma de Guerrero
Gabriela Campos Viguri Universidad Autónoma de Guerrero
Hilda Jiménez Wences Universidad Autónoma de Guerrero
Dinorah Nashely Martínez Carrillo Universidad Autónoma de Guerrero
Luz del Carmen Alarcón Romero Universidad Autónoma de Guerrero
Berenice Illades Aguiar Universidad Autónoma de Guerrero
Gloria Fernández Tilapa Universidad Autónoma de Guerrero
José Guadalupe Muñoz Camacho Instituto Estatal de Cancerología Dr. Arturo Beltrán Ortega
Marco Antonio Jiménez López Instituto Estatal de Cancerología Dr. Arturo Beltrán Ortega
Víctor Hugo Garzón Barrientos Instituto Estatal de Cancerología Dr. Arturo Beltrán Ortega
Óscar Peralta Zaragoza operalta@correo.insp.mx

Published 2015-01-12

Keywords

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How to Cite

Methylation of miR-218-1 in squamous intraepithelial lesions of low grade and cervical cancer with HPV 16. (2015). Acta Universitaria, 24, 35-38. https://doi.org/10.15174/au.2014.720

Abstract

The alterations in the expression of some microRNAs (miRNAs) in cervical carcinogenesis seems to be related to the aberrant methylation of their promoters. This study evaluates the methylation frequencies of microRNA-218-1 (miR-218-1)’s promoter in low grade squamous intraepithelial lesions (LGSIL) and cervical cancer (CC) with Human Papillomavirus type 16 (HPV-16). In addition,16 samples with LGSIL and 16 with CC were included. The methylation status was performed with qPCR Epitect Methyl II Arrays. The promoter of miR-218-1 was found methylated in 43.75% (7/16) in CC and 6.25% (1/16) in LGSIL (p = 0.037). The promoter of miR-218-1 was found methylated in a higher percentage in CC samples than in LGSIL. It is possible that promoter methylation of miR-218-1 to be an epigenetic mechanism involved in their aberrant expression in CC.

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References