Vol. 25 (2015): (NE-1) Ciencias Médicas
Artículos de investigación

Local levels of inflammatory markers in gingival crevicular fluid in newly diagnosed type 2 diabetics with chronic periodontitis

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  • Sandra Estefanía Almaguer García,
  • Martha Eugenia Fajardo Araujo,
  • Miriam Lucía Rocha Navarro,
  • Mary Fafutis Morris,
  • Juan Pablo Díaz Aguirre,
  • Sandra Laura García Gallardo
Sandra Estefanía Almaguer García Universidad de Guanajuato

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Martha Eugenia Fajardo Araujo Universidad de Guanajuato

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Miriam Lucía Rocha Navarro Universidad De LaSalle Bajío

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Mary Fafutis Morris Universidad de Guadalajara

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Juan Pablo Díaz Aguirre Universidad De Lasalle Bajío
Sandra Laura García Gallardo Universidad De LaSalle Bajío

Published 2015-07-13

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How to Cite

Local levels of inflammatory markers in gingival crevicular fluid in newly diagnosed type 2 diabetics with chronic periodontitis. (2015). Acta Universitaria, 25, 3-8. https://doi.org/10.15174/au.2015.743

Abstract

Immune system of diabetic subject is altered due to diabetes mellitus affecting periodontal tissue. This work evaluates inflammatory markers IL-2, IL-6 and IL-8 in gingival crevicular fluid of patients with Type 2 Diabetes Mellitus (T2DM). Participants were grouped into four groups: 1) healthy (n = 20); 2) with periodontitis (PCM, n = 20); 3) ≤1 year with diabetes and periodontitis ((DMT2 ≥ 10+PCM, n = 20); and 4)  ≥ 10 years diabetic and periodontitis (DMT2 ≥ 10 + PCM, n =  20). Cytokines were quantified by flow cytometry. The (DMT2 ≥ 10+PCM group showed higher levels of IL-2 respect to the other groups, as elevated levels of IL-6 respect to the PCM. The levels of IL-8 were higher in the healthy group compared to other groups. (DMT2 ≥ 10 + PCM subjects showed a destructive periodontal tissue adaptive immune response compared to (DMT2 ≥ 1 + PCM which show an immunological disturbance.


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References