Vol. 25 (2015): (NE-1) Ciencias Médicas
Artículos de investigación

Genetic markers associated with the development of metabolic syndrome and risk of coronary heart disease

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  • Eugenia Flores-Alfaro,
  • Miguel Cruz-López,
  • Luz del Carmen Alarcón-Romero,
  • María Elena Moreno-Godínez,
  • Oscar del Moral-Hernández,
  • Amalia Vences-Velázquez,
  • Carlos Ortuño-Pineda,
  • Marco Antonio Leyva-Vázquez,
  • Vianet Argelia Tello-Flores,
  • José Ángel Cahua-Pablo,
  • Diana Lizzete Antúnez-Ortiz,
  • Abigail Méndez-Palacios,
  • Adán Valladares-Salgado
Eugenia Flores-Alfaro Universidad Autónoma de Guerrero

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Miguel Cruz-López Hospital de Especialidades Centro Médico Siglo XXI, Instituto Mexicano del Seguro Social

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Luz del Carmen Alarcón-Romero Universidad Autónoma de Guerrero

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María Elena Moreno-Godínez Universidad Autónoma de Guerrero

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Oscar del Moral-Hernández Universidad Autónoma de Guerrero

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Amalia Vences-Velázquez Universidad Autónoma de Guerrero

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Carlos Ortuño-Pineda Universidad Autónoma de Guerrero

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Marco Antonio Leyva-Vázquez Universidad Autónoma de Guerrero

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Vianet Argelia Tello-Flores Universidad Autónoma de Guerrero

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José Ángel Cahua-Pablo Universidad Autónoma de Guerrero

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Diana Lizzete Antúnez-Ortiz Universidad Autónoma de Guerrero

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Abigail Méndez-Palacios Universidad Autónoma de Guerrero

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Adán Valladares-Salgado Hospital de Especialidades Centro Médico Siglo XXI, Instituto Mexicano del Seguro Social

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Published 2015-07-13

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How to Cite

Genetic markers associated with the development of metabolic syndrome and risk of coronary heart disease. (2015). Acta Universitaria, 25, 9-13. https://doi.org/10.15174/au.2015.751

Abstract

Genetic variants have been associated with diseases of complex traits and risk factors associated to them. The purpose of this study was to evaluate the association between several Single Nucleotide Polymorphisms (SNPs) with metabolic syndrome (MetS) and the atherogenic index of plasma (AIP). Guerrero women were studied. Somatometric measurements were performed, and blood biomarkers were determined. SNPs were identified in seven genes by real-time polymerase chain reaction (PCR). Decreased adiponectin in women with MetS and with greater atherogenic risk was observed, and associations between APOE with elevated levels of low-density lipoprotein (LDL)-cholesterol and triglycerides, the SNPrs1501299 with the AIP, the AA/rs708272 and GG/rs1884051 genotypes, with high LDL levels and genotype AA/rs854560 with LDL-c and paraoxonase activity. The results indicate that blood and genetic biomarkers might be involved in metabolic alterations and thus increase the individual's risk for disease development.

 
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References