Vol. 25 (2015): (NE-1) Ciencias Médicas
Artículos de investigación

Effect of oseltamivir and some vitamins on Dopamine, GSH and Lipid Peroxidation levels in young animal models exposed to O3

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  • David Calderón Guzmán,
  • Jonas Attilus,
  • Hugo Juárez Olguín,
  • Ernestina Hernández García,
  • Norma Osnaya Brizuela,
  • Maribel Ortiz Herrera,
  • Gerardo Barragán Mejía
David Calderón Guzmán Laboratorio de Neuroquímica, Instituto Nacional de Pediatría (INP

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Jonas Attilus Laboratorio de Neuroquímica, Instituto Nacional de Pediatría (INP

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Hugo Juárez Olguín Laboratorio de Farmacología, Instituto Nacional de Pediatría (INP)
Ernestina Hernández García Laboratorio de Farmacología, Instituto Nacional de Pediatría (INP)
Norma Osnaya Brizuela Laboratorio de Neuroquímica, Instituto Nacional de Pediatría (INP
Maribel Ortiz Herrera Laboratorio de Bacteriología Experimental, Instituto Nacional de Pediatría (INP)
Gerardo Barragán Mejía Laboratorio de Neuroquímica, Instituto Nacional de Pediatría (INP)

Published 2015-07-13

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How to Cite

Effect of oseltamivir and some vitamins on Dopamine, GSH and Lipid Peroxidation levels in young animal models exposed to O3. (2015). Acta Universitaria, 25, 26-31. https://doi.org/10.15174/au.2015.757

Abstract

Oseltamivir is used for the treatment of AH1N1 swine influenza in Mexico. The aim of the present study was to analyze the effect of oseltamivir on dopamine levels in patients exposed to vitamins A, D, and C as well as to ozone. For this, forty male Wistar rats (80 g) were divided into 6 groups. A combination of oseltamivir (20 vmg/kg) with A (39 v0UI.), C (30 mg) and D (60 UI.) vitamins with or without ozone 0.5 ppm were intraperitoneally administered for 5 days. The exposition to ozone was through a camera controlled. The animals were sacrificed and the brain dissected in cortex (I), hemispheres (II) and cerebellum/medulla oblongata (III) to measure dopamine, glutathione (GSH) and lipoperoxidation using fluorescence. Dopamine increased in I, II and III regions while GSH increased only in II and III regions and lipoperoxidation decreased in the same regions. This changes were significant (p < 0.05) in the groups that received oseltamivir and ozone. Administration of oseltamivir and ozone induces synergic effect on dopamine metabolism.


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