Vol. 26 No. 3 (2016)
Artículos de investigación

Antioxidant activity and antimicrobial evaluation of 1-benzyl-1,2,3-triazole

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  • Juan I. Sarmiento-Sánchez,
  • Julio Montes-Ávila,
  • Francisco Delgado-Vargas,
  • Ignacio A. Rivero,
  • Sylvia P. Díaz-Camacho,
  • Magdalena Uribe-Beltrán
Juan I. Sarmiento-Sánchez Autonomous University of Sinaloa

Bio
Julio Montes-Ávila Autonomous University of Sinaloa

Bio
Francisco Delgado-Vargas Autonomous University of Sinaloa

Bio
Ignacio A. Rivero Technological Institute of Tijuana

Bio
Sylvia P. Díaz-Camacho Autonomous University of Sinaloa

Bio
Magdalena Uribe-Beltrán Autonomous University of Sinaloa

Bio

Published 2016-07-11

Keywords

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How to Cite

Antioxidant activity and antimicrobial evaluation of 1-benzyl-1,2,3-triazole. (2016). Acta Universitaria, 26(3), 63-67. https://doi.org/10.15174/au.2016.937

Abstract

This paper reports biological activities of 1-benzyl-1,2,3-triazoles: antimicrobial by broth microdilution method, antioxidant by DPPH (2,2-diphenyl-1-picrylhydrazyl)• inactivation assay and toxicity by brine shrimp (Artemia salina) assay. The compound 1-(1-Benzyl-1H-1,2,3-triazol-4-yl) cyclopentanol (50 µg/mL to 200 µg/mL) presented selective moderate inhibition of Staphylococcus aureus 3 growth whereas the same effect of 3-(1-Benzyl-1H-1,2,3-triazol-4-yl)propan-1-ol was registered against Escherichia coli AO11, E. coli AO15 and Salmonella enterica serovar Typhi. 5g-i compounds showed the highest DPPH• scanvenging. Synthetic 1,2,3-triazole evaluated compounds were classified in the range moderately toxic to non-toxic. Thus, based in the previously/actually published information, they could be a source of compounds with biological activities of importance for human health.

 
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