The International Diabetes Federation (IDF) and the National Cholesterol Education Program at the III Adult Treatment Panel (NCEP-ATPIII), have proposed criteria for the Metabolic Syndrome (MS) diagnosis in adolescents. This study determines the MS prevalence and its link to other parameters (uric acid, platelets, and blood type) in adolescents of 12-16 years. A descriptive and transversal study, using IDF, NCEP-ATPIII criteria and proposed criteria (PC). Sample consisted of 246 adolescents, according to the IDF the MS prevalence was 3.25%, 6.5% according to the NCEP-ATPIII and 21.54% for the proposed criteria, being women and Mennonites the most affected. Levels of uric acid, platelets and the Rh factor did not show any link with MS, unlike the blood type. The application of different diagnosis criteria, would mean not properly identifying the presence of this syndrome.