Vol. 29 (2019)
Artículos de investigación

Effect of pomegranate juice (Punica Granatum) on behavioral patterns of intake in rats with induced diabetes

HTML (Spanish) PDF (Spanish) XML (Spanish)
  • Elia Herminia Valdés Miramontes,
  • Carmen Alejandrina Virgen-Carrillo,
  • Alma Gabriela Martínez Moreno,
  • Jessica Elizabeth Pineda-Lozano,
  • Verónica Fonseca-Bustos
Elia Herminia Valdés Miramontes
Carmen Alejandrina Virgen-Carrillo Centro de Investigaciones en Comportamiento Alimentario y Nutrición (CICAN), Centro Universitario del Sur, Universidad de Guadalajara.

Bio
Alma Gabriela Martínez Moreno
Jessica Elizabeth Pineda-Lozano
Verónica Fonseca-Bustos

Published 2019-08-15

Copyright Notice

How to Cite

Effect of pomegranate juice (Punica Granatum) on behavioral patterns of intake in rats with induced diabetes. (2019). Acta Universitaria, 29, 1-9. https://doi.org/10.15174/au.2019.1997

Abstract

Evidence on the alternative treatment of diabetes mellitus is now growing through functional foods such as pomegranate juice. Most studies focus on the physiological effect of juice when administered by gavage to diabetic rats. The objective was to evaluate the effect of free access to pomegranate juice exposure on the consumption of liquids, food intake, and body weight in diabetic rats. Two groups of six healthy rats and six hyperglycemic rats, induced with 60 mg/kg of intraperitoneal streptozotocin, were exposed to pomegranate juice, water, and food for 21 days. The results showed significant differences (p < 0.05) in fluid consumption and body weight in both groups. There were no significant differences in food intake (p > 0.05). The free access exposure to pomegranate juice showed its acceptance and generated behavioral differences in the intake.

HTML (Spanish) PDF (Spanish) XML (Spanish)

References

  1. Aboonabi, A., Rahmat, A., & Othman, F. (2014). Antioxidant effect of pomegranate against streptozotocin-nicotinamide generated oxidative stress induced diabetic rats. Toxicology Reports, 1, 915–922. doi:10.1016/j.toxrep.2014.10.022
  2. Al-Olayan, E. M., El-Khadragy, M. F., Metwally, D. M., & Abdel Moneim, A. E. (2014). Protective effects of pomegranate (Punica granatum) juice on testes against carbon tetrachloride intoxication in rats. BMC Complementary and Alternative Medicine, 14(1), 1-9. doi:10.1186/1472-6882-14-164
  3. Akbarzadeh, A., Norouzian, D., Mehrabi, M. R., Jamshidi, S., Farhangi, A., Verdi, A. A., … Rad, B. L. (2007). Induction of diabetes by Streptozotocin in rats. Indian Journal of Clinical Biochemistry, 22(2), 60–64. doi:10.1007/BF02913315
  4. Bagri, P., Ali, M., Aeri, V., Bhowmik, M., & Sultana, S. (2009). Antidiabetic effect of Punica granatum flowers: Effect on hyperlipidemia, pancreatic cells lipid peroxidation and antioxidant enzymes in experimental diabetes. Food and Chemical Toxicology, 47(1), 50–54. doi:10.1016/j.fct.2008.09.058
  5. Banihani, S. A., Makahleh, S. M., El-Akawi, Z., Al-Fashtaki, R. A., Khabour, O. F., Gharibeh, M. Y., … Al-Khasieb, N. J. (2014). Fresh pomegranate juice ameliorates insulin resistance, enhances β-cell function, and decreases fasting serum glucose in type 2 diabetic patients. Nutrition Research, 34(10), 862–867. doi:10.1016/j.nutres.2014.08.003
  6. Bhaskar, A., & Kumar, A. (2012). Antihyperglycemic, antioxidant and hypolipidemic effect of Punica granatum L flower extract in streptozotocin induced diabetic rats. Asian Pacific Journal of Tropical Biomedicine, 2(3), 1764–1769. doi:10.1016/S2221-1691(12)60491-2
  7. Bolsinger, J., Pronczuk, A., Sambanthamurthi, R., & Hayes, K. C. (2014). Anti-diabetic effects of palm fruit juice in the Nile rat (Arvicanthis niloticus). Journal of Nutritional Science, 3(5). doi:10.1017/jns.2014.3
  8. Booth, D. A. (1972). Some characteristics of feeding during streptozotocin-induced diabetes in the rat. Journal of Comparative and Physiological Psychology, 80(2), 238–249. doi:10.1037/h0032968
  9. De Castro, J. M., & Balagura, S. (1975). Meal patterning in the streptozotocin-diabetic rat. Physiology & Behavior, 15(3), 259–263. doi:10.1016/0031-9384(75)90091-8
  10. Farias, M., Wohlenberg, L. K., Gonçalves, T. K., Schaffer, D. K., Hilger, R. D., Braccini Neto, C., … Funchal, C. D. (2015). Effect of grape juice on some biochemical and oxidative stress parameters in serum and liver enzymes of pregnant and lactating rats. Issues in Biological Sciences and Pharmaceutical Research, 3(4), 37–46. doi:10.15739/ibspr.011
  11. Flores, C. J. (2011). De los modelos animales a la práctica psicológica: el surgimiento de algunas técnicas aplicadas a problemas de salud. Suma Psicológica, 18(1), 115–123. Recuperado de http://www.redalyc.org/pdf/1342/134218661011.pdf
  12. Granneman, J., & Stricker, E. (1984). Food intake and gastric emptying in rats with streptozotocin-induced diabetes. American Journal of Physiology, 247(6), 1054–1061. Recuperado de http://citeseerx.ist.psu.edu/viewdoc/download;jsessionid=A43D27A77C4B637A8AF872FAA3364393?doi=10.1.1.913.2255&rep=rep1&type=pdf
  13. Hallfrisch, J., Lev Lazar, F., & Reiser, S. (1979). Effect of feeding sucrose or starch to rats made diabetic with streptozotocin. The Journal of nutrition, 109(11), 1909–1915. Recuperado de http://jn.nutrition.org/content/109/11/1909.extract
  14. Hernandez, L., & Briese, E. (1972). Analysis of diabetic hyperphagia and polydipsia. Physiology & Behavior, 9(5), 741–746. doi:10.1016/0031-9384(72)90044-3
  15. Lee, C.-J., Chen, L.-G., Liang, W.-L., & Wang, C.-C. (2010). Anti-inflammatory effects of Punica granatum Linne in vitro and in vivo. Food Chemistry, 118(2), 315–322. doi:10.1016/j.foodchem.2009.04.123
  16. Miguel, M., Neves, M., & Antunes, M. (2010). Pomegranate (Punica granatum L.): A medicinal plant with myriad biological properties - A short review. Journal of Medicinal Plants Research, 4(25), 2836–2847. Recuperado de http://www.academicjournals.org/article/article1380714856_Miguel%20et%20al.pdf
  17. Mirmiran, P., Bahadoran, Z., & Azizi, F. (2014). Functional foods-based diet as a novel dietary approach for management of type 2 diabetes and its complications: A review. World Journal of Diabetes, 5(3), 267-281. doi:10.4239/wjd.v5.i3.267
  18. Miyata, M., Takano, H., Q.Guo, L., Nagata, K., & Yamazoe, Y. (2004). Grapefruit juice intake does not enhance but rather protects against aflatoxin B1-induced liver DNA damage through a reduction in hepatic CYP3A activity. Carcinogenesis, 25(2), 203–209. doi:10.1093/carcin/bgg194
  19. Osman, H., Eshak, M., El-Sherbiny, E., & Bayoumi, M. (2012). Biochemical and genetical evaluation of pomegranate impact on diabetes mellitus induced by alloxan in female rats. Life Science Journal, 9(3), 1543–1553. Recuperdo de
  20. http://www.lifesciencesite.com/lsj/life0903/225_10224life0903_1543_1553.pdf
  21. Pathak, M. (2014). Diabetes mellitus type 2 and functional foods of plant origin. Recent Patents on Biotechnology, 8(2), 160–164. doi:10.2174/1872208309666140904120633
  22. Prasetyastuti, Anthony, M. W. P., Rahman, N. A., Ngadikun, & Sunarti. (2014). Hypoglycemic and antioxidative effects of pomegranate (Punica granatum L.) juice in streptozotocin induced diabetic rats. Pakistan Journal of Nutrition, 13(10), 567–572. doi:10.3923/pjn.2014.567.572
  23. Ribes, E. (2011). ¿Por qué es necesario estudiar el comportamiento animal? Suma Psicológica, 18(1), 9–15. Recuperado de http://www.scielo.org.co/pdf/sumps/v18n1/v18n1a02.pdf
  24. Richter, C. P. (1941). Behavior and endocrine regulators of the internal environment. Endocrinology, 28(2), 193–195. doi:10.1210/endo-28-2-193
  25. Richter, C. P., & Schmidt, E. C. H. (1941). Increased fat and decreased carbohydrate appetite of pancreatectomized rats. Endocrinology, 28(2), 179–192. doi:10.1210/endo-28-2-179
  26. Richter, C. (1943). Total self-regulatory functions in animals and human beings. Harvey Lecture Series, 38, 63–103. Recuperado de https://www.ssib.org/web/classics/Richter%20Self%20regulatory%20functions%20Harvey%20Lect%201943.pdf
  27. Smith, J. C., & Gannon, K. S. (1991). Ingestion patterns of food, water, saccharin and sucrose in streptozotocin-induced diabetic rats. Physiology & Behavior, 49(1), 189–199. doi:10.1016/0031-9384(91)90253-K
  28. Sreekumar, S., Sithul, H., Muraleedharan, P., Azeez, J. M., & Sreeharshan, S. (2014). Pomegranate Fruit as a rich source of biologically active compounds. BioMed Research International, 2014, 1–12. doi:10.1155/2014/686921
  29. Taheri Rouhi, S. Z., Sarker, M. M. R., Rahmat, A., Alkahtani, S. A., & Othman, F. (2017). The effect of pomegranate fresh juice versus pomegranate seed powder on metabolic indices, lipid profile, inflammatory biomarkers, and the histopathology of pancreatic islets of Langerhans in streptozotocin-nicotinamide induced type 2 diabetic Sprague–Dawley rats. BMC Complementary and Alternative Medicine, 17(1). doi:10.1186/s12906-017-1667-6
  30. Tsang, C., Smail, N. F., Almoosawi, S., Davidson, I., & Al-Dujaili, E. A. S. (2012). Intake of polyphenol-rich pomegranate pure juice influences urinary glucocorticoids, blood pressure and homeostasis model assessment of insulin resistance in human volunteers. Journal of Nutritional Science, 1. doi:10.1017/jns.2012.10
  31. Viuda-Martos, M., Fernández-López, J., & Pérez-Ãlvarez, J. A. (2010). Pomegranate and its many functional components as related to human health: A review. Comprehensive Reviews in Food Science and Food Safety, 9(6), 635–654. doi:10.1111/j.1541-4337.2010.00131.x
  32. Wang, R., Ding, Y., Liu, R., Xiang, L., & Du, L. (2010). Pomegranate: constituents, bioactivities, and pharmacokinetics. Fruit, Vegetable and Cereal Science and Biotechnology, 4(2), 77–87. Recuperado de http://www.globalsciencebooks.info/Online/GSBOnline/images/2010/FVCSB_4(SI2)/FVCSB_4(SI2)77-87o.pdf