Renal function in children with obesity and metabolic syndrome

Abstract

Obesity in Mexico is a Public Health problem. The objective of this study is to evaluate kidney function in obese children with and without metabolic syndrome (MS), in relation to healthy subjects. For this, weight, height, mid-upper arm circumference (MUAC), waist circumference (WC), body surface area (BSA), body mass index (BMI), glomerular filtration rate (GFR) (Schwarts) were taken. Glucose, creatinine, uric acid, total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), triglycerides and general urine test were taken also. 128 Pediatric patients studied were formed into three groups (healthy, obese with and without MS), with an age of 11.04 ± 2.63 years. Obese males with MS had significant increase in glucose (p = 0.04) and triglycerides (p = 0.0033); obese women had a significant elevation of glucose (p = 0.042) and triglycerides (p = 0.022). The two groups with obesity showed increase in GFR (Hyperfiltration), in comparison to healthy controls. Possible hyperinsulinemia in patients, produces hypertrophy and glomerular hyperfiltration. Obese patients with and without MS, had impaired kidney function.