Sierra Gorda of Guanajuato Biosphere Reserve (SGGBR), is the most important natural area from the State of Guanajuato mostly due to its biological richness. Visual interpretation of orthophotos and SPOT 5 image processing were used to determine land use/cover change for 2004 – 2011 period. Forest degradation (FD) was calculated by correlation of tree conservation degree and areal biomass points data information from National Forest Inventory and Soil; as well land use/cover change determination and soil erosion information during 2004 – 2011 period. Of total vegetation cover, 45% presented moderate to very high values of FD, 16% showed low FD and 13% presented no degradation. Considering that study area holds the highest category in the National System Natural Protected Areas, results suggest there is a rather defficient use and management of natural resources.