A descriptive analysis was conducted using three secondary sources of information in national official records: road accidents, externally caused injuries and occupational diseases. Data used corresponded to cargo drivers in Mexico from 2011 to 2015. Results show that road drivers have a higher risk of death by accident (Rate Ratio [RR] = 4.84, 95% Confidence Intervals [CI 4.48, 5.23]) and occupational diseases (RR = 1.53, 95% CI [ 1.46, 1.61]) than average Mexican workers. The main causes of disability in heavy cargo drivers are related to musculoskeletal disorders, or they acknowledge obesity as a risk factor (14% and 40% respectively). Heavy cargo vehicles also have the highest risk of death by collision (RR = 3.42, 95% CI [3.19, 3.65]). Driving cargo vehicles is one of the most dangerous activities in terms of work-related diseases and risk factors.