Introduction. Since 1990, the combination of structural reforms in Latin America and United States (US) anti-immigration policies have resulted in an increase in poverty, unemployment, and Hispanic migration to that country. Objectives: To analyze regional unemployment and the migration phenomenon based on the relationship between neoliberalism in Latin America and US anti-immigration policies. Method. Deductive and comparative based on data collection of unemployment and immigration in Latin America and US anti-immigration policies. Outcomes. To show the increasing level of unemployment in Latin America, the growing immigration rate to the United States, and the changing profile of Hispanic immigrants. Conclusion. Rather than avoiding legal or illegal entry of Hispanics into the United States, its anti-immigrant policies have intensified selective immigration policies.