Genotoxicity and cytotoxicity were evaluated in peripheral blood of mice CD-1 exposed to heavy metals: chromium and thallium (Cr [VI] y Tl [I]). Groups of five animals were treated intraperitoneally with 20 mg/kg of CrO3 or with 30 mg/kg de Tl2SO4. The genetic damage was determined by the kinetic of micronucleus (MN) and apoptosis induction, while the cellular toxicity by the relationship between the polychromatic/normochromatic erythrocytes (EPC/ENC) and cell viability. Evaluations were performed at 0 h, 24 h, 48 h and 72 h after treatment. The results had shown a significant increment in the MN, apoptotic cells and non-viable cells with both treatments. Particularly, the cell and general toxicity was increased in mice exposed to Tl2SO4. Based on the results, it can be suggested that the exposition to metal compounds such as Cr (VI) and Tl (I) represent a genetic and cytotoxic risk for the human populations.