Vol. 26 No. 1 (2016)
Artículos de Investigación

Association of MTHFR C677T polymorphism with symptomatic predominance in a sample of schizophrenic patients from Jalisco, Mexico

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  • Ricardo Ignacio Audiffred Jaramillo,
  • Teresa Arcelia García Cobián,
  • Javier Eduardo García de Alba García,
  • Edy David Rubio Arellano
Ricardo Ignacio Audiffred Jaramillo
Secretaría de Salud
Bio
Teresa Arcelia García Cobián
Universidad de Guadalajara
Bio
Javier Eduardo García de Alba García
Instituto Mexicano del Seguro Social (IMSS)
Bio
Edy David Rubio Arellano
Universidad de Guadalajara
Bio
DOI: https://doi.org/10.15174/au.2016.838

Published 2016-02-22

Keywords

  • Esquizofrenia,
  • Polimorfismo MTHFR C677T,
  • escala PANSS,
  • México.
  • Schizophrenia,
  • MTHFR C677T polymorphism,
  • PANSS scale,
  • Mexico.

How to Cite

Audiffred Jaramillo, R. I., García Cobián, T. A., García de Alba García, J. E., & Rubio Arellano, E. D. (2016). Association of MTHFR C677T polymorphism with symptomatic predominance in a sample of schizophrenic patients from Jalisco, Mexico. Acta Universitaria, 26(1), 56–64. https://doi.org/10.15174/au.2016.838

Abstract

Schizophrenia is a severe mental illness that has been recently associated with some genetic mutations as MTHFR C677T polymorphism. The objective was to evaluate the statistic association of MTHFR C677T polymorphism with symptomatic predominance in a sample of schizophrenic patients from Jalisco, Mexico. The study has a descriptive, retrospective, cross-sectional design, which analyzed a total of 49 patients classified by their symptomatic predominance with the Positive and Negative Syndrome Scale (PANSS) scale to determine their association with any polymorphism of MTHFR C677T polymorphism. The sample was in Hardy-Weinberg equilibrium. The allele frequency for T was 51% and for homozygous TT 31%. No statistic difference between genotypes and symptomatic predominance: CC/CT(p = 0.72), CC/TT (p = 0.84), CT/TT (p = 0.88). The homozygous T and positive symptoms were more frequent in women. In contrast, the heterozygous CT and negative symptoms had more prevalence in men. The thermolabile variant of MTHFR gene (homozygous T) in schizophrenic patients, is not related to present symptomatic predominance.

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