Vol. 24 (2014): (NE-2) Ciencias Médicas
Artículos de Investigación

IFN-γ, IL-4 and Helicobacter pylori in patients with chronic gastritis and gastric cáncer

Alina Mora González
Universidad Autónoma de Guerrero
Víctor Manuel Villegas Román
Universidad Autónoma de Guerrero
Josefina Atrisco Morales
Universidad Autónoma de Guerrero
Dinorah Nashely Martínez Carrillo
Universidad Autónoma de Guerrero
Gloria Fernández Tilapa
Universidad Autónoma de Guerrero
Rogelio Hernández Pando
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
Salomón Reyes Navarrete
Instituto Estatal de Cancerología
Reyes Betancourt Linares
Unidad Especializada en Gastroenterología Endoscopía,
Iván Cruz del Carmen
Hospital General Dr. Raymundo Abarca Alarcón
Berenice Illades Aguiar
Universidad Autónoma de Guerrero
Adolfo Román Román
Universidad Autónoma de Guerrero

Published 2015-01-12

Keywords

  • Cáncer gástrico,
  • gastritis crónica,
  • H. pylori,
  • IFN-γ,
  • IL-4.
  • Gastric cancer,
  • chronic gastritis,
  • H. pylori,
  • IFN-γ,
  • IL-4.

How to Cite

Mora González, A., Villegas Román, V. M., Atrisco Morales, J., Martínez Carrillo, D. N., Fernández Tilapa, G., Hernández Pando, R., Reyes Navarrete, S., Betancourt Linares, R., Cruz del Carmen, I., Illades Aguiar, B., & Román Román, A. (2015). IFN-γ, IL-4 and Helicobacter pylori in patients with chronic gastritis and gastric cáncer. Acta Universitaria, 24, 30–34. https://doi.org/10.15174/au.2014.719

Abstract

The Helicobacter pylori infection is the main factor of risk for gastric cancer, in the immune response induced for the bacterium there is an infiltration of cells which produce high levels of cytokines, which may be involved in gastric carcinogenesis. The objetive of this investigation is to evaluate the relation of the expression of IFN- γ and IL-4 with the H. pylori infection, chronic gastritis and gastric cancer. 100 patients with chronic gastritis and twenty with gastric cancer were included; the expression of INF-g and IL-4 was determined by immunohistochemistry. 57.5% of cases were positive for H. pylori, the highest frequency of IFN- γ expression was found in cases of cancer H. pylori-positive, in the case of IL-4 was more frequent in patients H. pylori-positive with chronic gastritis. The IFN- γ expression frequency was higher than the IL-4 expression. In the majority of the samples H. pylori-positive were expressed the two cytokines.