Relation of adipokines with markers of hepatic function in gestational diabetes and normoglycemic pregnancy

Abstract

This is an analytical cross-sectional study whose objective was to evaluate the relation of adipokines with markers of hepatic function in 100 patients with gestational diabetes mellitus (GDM) and 100 controls. Multivariate lineal regression was performed for each hepatic marker, adjusted by age, anthropometric characteristics, parity, and family history of type 2 diabetes mellitus. In GDM, resistin and neutrophil gelatinase-associated lipocalin (NGAL) correlated with low-density lipoproteins (LDL) and leptin with indirect bilirubin. In controls, NGAL correlated with triglycerides, with very low-density lipoproteins (VLDL), and with direct bilirubin; leptin correlated with various fractions of bilirubin; and lastly, C-reactive protein correlated with high-density lipoproteins (HDL), aspartate aminotransferase (AST), albumin, and total proteins. In conclusion, results suggest a physiological interaction between adipose tissue and the liver during pregnancy, regardless of the presence or absence of GDM.