Genetic markers associated with the development of metabolic syndrome and risk of coronary heart disease

Abstract

Genetic variants have been associated with diseases of complex traits and risk factors associated to them. The purpose of this study was to evaluate the association between several Single Nucleotide Polymorphisms (SNPs) with metabolic syndrome (MetS) and the atherogenic index of plasma (AIP). Guerrero women were studied. Somatometric measurements were performed, and blood biomarkers were determined. SNPs were identified in seven genes by real-time polymerase chain reaction (PCR). Decreased adiponectin in women with MetS and with greater atherogenic risk was observed, and associations between APOE with elevated levels of low-density lipoprotein (LDL)-cholesterol and triglycerides, the SNPrs1501299 with the AIP, the AA/rs708272 and GG/rs1884051 genotypes, with high LDL levels and genotype AA/rs854560 with LDL-c and paraoxonase activity. The results indicate that blood and genetic biomarkers might be involved in metabolic alterations and thus increase the individual's risk for disease development.