Vol. 33 (2023)
Artículos de Investigación

Relation of adipokines with markers of hepatic function in gestational diabetes and normoglycemic pregnancy

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  • Renata Saucedo,
  • María Isabel Peña-Cano,
  • Yolanda García,
  • Rebeca González Reynoso,
  • Mary Flor Díaz-Velázquez,
  • Jorge Valencia Ortega
Renata Saucedo
Unidad de Investigación Médica de Enfermedades Endocrinas, Hospital de Especialidades, CMN Siglo XXI, Instituto Mexicano del Seguro Social
María Isabel Peña-Cano
Hospital de Gineco Obstetricia No. 221, Instituto Mexicano del Seguro Social.
Yolanda García
Unidad de Investigación Médica de Enfermedades Endocrinas, Hospital de Especialidades, CMN Siglo XXI, Instituto Mexicano del Seguro Social
Rebeca González Reynoso
Unidad de Investigación Médica de Enfermedades Endocrinas, Hospital de Especialidades, CMN Siglo XXI, Instituto Mexicano del Seguro Social
Mary Flor Díaz-Velázquez
Hospital de Gineco Obstetricia No. 3, CMN La Raza, Instituto Mexicano del Seguro Social
Jorge Valencia Ortega
IMSS
DOI: https://doi.org/10.15174/au.2023.3711

Published 2023-07-26

How to Cite

Saucedo, R. ., Peña-Cano, M. I. ., García, Y. ., González Reynoso, R. ., Díaz-Velázquez, M. F. ., & Valencia Ortega, J. (2023). Relation of adipokines with markers of hepatic function in gestational diabetes and normoglycemic pregnancy. Acta Universitaria, 33, 1–14. https://doi.org/10.15174/au.2023.3711

Abstract

This is an analytical cross-sectional study whose objective was to evaluate the relation of adipokines with markers of hepatic function in 100 patients with gestational diabetes mellitus (GDM) and 100 controls. Multivariate lineal regression was performed for each hepatic marker, adjusted by age, anthropometric characteristics, parity, and family history of type 2 diabetes mellitus. In GDM, resistin and neutrophil gelatinase-associated lipocalin (NGAL) correlated with low-density lipoproteins (LDL) and leptin with indirect bilirubin. In controls, NGAL correlated with triglycerides, with very low-density lipoproteins (VLDL), and with direct bilirubin; leptin correlated with various fractions of bilirubin; and lastly, C-reactive protein correlated with high-density lipoproteins (HDL), aspartate aminotransferase (AST), albumin, and total proteins. In conclusion, results suggest a physiological interaction between adipose tissue and the liver during pregnancy, regardless of the presence or absence of GDM.

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