Vol. 35 (2025): Volumen 35
Artículos de Investigación

CellCorticalDisplastic: simulador educativo de la recuperación de la desensibilización del receptor N-metil-D-aspartato

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  • Marleni Reyes Monreal,
  • María Eugenia Pérez Bonilla,
  • Jessica Quintero Pérez,
  • Arturo Reyes Lazalde,
  • María Beatriz Bernábe-Loranca
Marleni Reyes Monreal
Benemérita Universidad Autónoma de Puebla
María Eugenia Pérez Bonilla
Benemérita Universidad Autónoma de Puebla
Jessica Quintero Pérez
Benemérita Universidad Autónoma de Puebla
Arturo Reyes Lazalde
Facultad de Ciencias Biológicas, Benemérita Universidad Autónoma de Puebla
María Beatriz Bernábe-Loranca
Benemérita Universidad Autónoma de Puebla
DOI: https://doi.org/10.15174/au.2025.4187

Publicado 2025-06-04

Cómo citar

Reyes Monreal, M., Pérez Bonilla, M. E., Quintero Pérez, J., Reyes Lazalde, A., & Bernábe-Loranca, M. B. (2025). CellCorticalDisplastic: simulador educativo de la recuperación de la desensibilización del receptor N-metil-D-aspartato. Acta Universitaria, 35. https://doi.org/10.15174/au.2025.4187

Resumen

El receptor N-metil-D-aspartato (NMDA) constituye un componente importante de las sinapsis excitatorias. No existen simuladores educativos que aborden la recuperación de la desensibilización del receptor NMDA. En este contexto, se ha concebido un simulador educativo orientado a la enseñanza de este proceso. Para interesar a los alumnos, se basó en registros electrofisiológicos de la recuperación de la desensibilización en tres tipos de células de la corteza de un paciente pediátrico con displasia cortical: neuronas localizadas fuera de la corteza displásica (NO-CD), neuronas de la corteza displásica aparentemente normales (CD-aparentemente normales) y neuronas citomegálicas de la corteza displásica (CD-citomegálicas). El simulador reproduce la recuperación de la desensibilización de cada una de estas células, validando los procesos modelados. El modelo matemático implementado permitió estimar teóricamente la concentración de calcio interno en los experimentos reportados. El simulador cuenta con un conjunto de lecciones que introduce al alumno en el tema y permite realizar prácticas virtuales.

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Citas

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